SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.84A 1fm9A-4nhbA:
undetectable		 1fm9A-4nhbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.85A 1k74A-4nhbA:
undetectable		 1k74A-4nhbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		3 / 3 ASN A 131
ALA A 102
ASN A 319
 None
IOD  A 402 (-4.1A)
None
 0.79A 1n4fA-4nhbA:
undetectable		 1n4fA-4nhbA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.75A 1xlsA-4nhbA:
undetectable		 1xlsA-4nhbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.76A 1xlsB-4nhbA:
undetectable		 1xlsB-4nhbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.76A 1xlsC-4nhbA:
undetectable		 1xlsC-4nhbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.75A 1xlsD-4nhbA:
undetectable		 1xlsD-4nhbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.89A 2aclG-4nhbA:
undetectable		 2aclG-4nhbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 10 ALA A 327
ALA A 118
ARG A 119
LEU A 115
LEU A 235
 None
None
None
IOD  A 403 (-4.4A)
None
 1.12A 2bxqA-4nhbA:
undetectable		 2bxqA-4nhbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		3 / 3 SER A 211
THR A  92
GLN A  95
 G3P  A 414 ( 4.3A)
None
G3P  A 414 (-3.4A)
 0.82A 2fk8A-4nhbA:
undetectable		 2fk8A-4nhbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		3 / 3 TYR A  62
GLU A  56
TYR A  53
 None
 1.01A 3ug8A-4nhbA:
undetectable		 3ug8A-4nhbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 7 PRO A 212
ASP A 215
SER A  70
PHE A 194
 None
None
None
G3P  A 414 (-4.7A)
 1.30A 4ndnC-4nhbA:
undetectable		 4ndnC-4nhbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 7 PRO A 212
ASP A 215
SER A  70
PHE A 194
 None
None
None
G3P  A 414 (-4.7A)
 1.31A 4odjA-4nhbA:
undetectable		 4odjA-4nhbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 7 PRO A 212
ASP A 215
SER A  70
PHE A 194
 None
None
None
G3P  A 414 (-4.7A)
 1.25A 5a1iA-4nhbA:
undetectable		 5a1iA-4nhbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 6 ILE A  45
PHE A 146
HIS A 238
PHE A 246
 IOD  A 406 ( 4.7A)
None
G3P  A 414 (-3.9A)
None
 0.73A 5vkqA-4nhbA:
undetectable
5vkqB-4nhbA:
undetectable		 5vkqA-4nhbA:
11.72
5vkqB-4nhbA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 6 PHE A 246
ILE A  45
PHE A 146
HIS A 238
 None
IOD  A 406 ( 4.7A)
None
G3P  A 414 (-3.9A)
 0.73A 5vkqA-4nhbA:
undetectable
5vkqD-4nhbA:
undetectable		 5vkqA-4nhbA:
11.72
5vkqD-4nhbA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		5 / 12 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.79A 5z12B-4nhbA:
undetectable		 5z12B-4nhbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		4 / 7 PRO A 212
ASP A 215
SER A  70
PHE A 194
 None
None
None
G3P  A 414 (-4.7A)
 1.25A 6g6rA-4nhbA:
undetectable		 6g6rA-4nhbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Desulfovibrio
desulfuricans) 		3 / 3 TRP A 257
ILE A 258
ASP A 254
 None
 0.86A 6i0y7-4nhbA:
undetectable		 6i0y7-4nhbA:
5.44