SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 9 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.29A 1c9sA-4nhoA:
undetectable
1c9sB-4nhoA:
undetectable
1c9sA-4nhoA:
9.43
1c9sB-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.29A 1c9sB-4nhoA:
undetectable
1c9sC-4nhoA:
undetectable
1c9sB-4nhoA:
9.43
1c9sC-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.30A 1c9sG-4nhoA:
undetectable
1c9sH-4nhoA:
undetectable
1c9sG-4nhoA:
9.43
1c9sH-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 9 VAL A 532
VAL A 500
LEU A 515
ILE A 472
ALA A 524
None
CSO  A 519 ( 4.6A)
None
HG  A 909 (-3.6A)
None
1.08A 1eqgA-4nhoA:
undetectable
1eqgA-4nhoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 VAL A 532
VAL A 500
LEU A 515
ILE A 472
ALA A 524
None
CSO  A 519 ( 4.6A)
None
HG  A 909 (-3.6A)
None
1.09A 1eqgB-4nhoA:
undetectable
1eqgB-4nhoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.29A 1gtfC-4nhoA:
undetectable
1gtfD-4nhoA:
undetectable
1gtfC-4nhoA:
9.43
1gtfD-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 1gtfG-4nhoA:
undetectable
1gtfH-4nhoA:
undetectable
1gtfG-4nhoA:
9.43
1gtfH-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 1gtfH-4nhoA:
undetectable
1gtfI-4nhoA:
undetectable
1gtfH-4nhoA:
9.43
1gtfI-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 12 ILE A 503
LEU A 480
ALA A 481
LEU A 529
PHE A 559
None
None
None
None
SO4  A 902 ( 4.9A)
1.05A 1og5B-4nhoA:
undetectable
1og5B-4nhoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 GLY A 433
ALA A 421
THR A 381
ILE A 431
ARG A 374
None
1.31A 1utdM-4nhoA:
undetectable
1utdN-4nhoA:
undetectable
1utdM-4nhoA:
9.43
1utdN-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 8 MET A 588
ARG A 623
PRO A 387
GLY A 384
None
None
None
SO4  A 904 (-3.5A)
1.05A 2qd3A-4nhoA:
2.9
2qd3A-4nhoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 8 SER A 378
ASP A 376
ARG A 757
ALA A 632
None
CXS  A 908 (-3.9A)
None
None
1.29A 2rk8A-4nhoA:
undetectable
2rk8A-4nhoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 GLU A 413
GLY A 410
CYH A 409
LEU A 495
ILE A 406
None
1.47A 3adsA-4nhoA:
undetectable
3adsA-4nhoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 5 VAL A 547
VAL A 603
GLN A 575
ARG A 622
None
1.28A 3bjwH-4nhoA:
undetectable
3bjwH-4nhoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 5 VAL A 547
VAL A 603
GLN A 575
ARG A 622
None
1.39A 3bjwB-4nhoA:
undetectable
3bjwB-4nhoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 6 ILE A 521
THR A 442
PHE A 605
TYR A 545
None
SO4  A 901 (-4.0A)
None
None
1.18A 3elzB-4nhoA:
undetectable
3elzB-4nhoA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 THR A 381
VAL A 626
ILE A 431
ILE A 424
PRO A 624
None
1.24A 3kpcA-4nhoA:
undetectable
3kpcA-4nhoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 9 PHE A 445
VAL A 603
LEU A 480
GLU A 550
ALA A 475
None
1.10A 3mdvA-4nhoA:
undetectable
3mdvA-4nhoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
3 / 3 TYR A 537
LEU A 567
LYS A 565
None
GOL  A 906 (-3.4A)
None
0.74A 3sueD-4nhoA:
undetectable
3sueD-4nhoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 12 ILE A 473
ALA A 481
ILE A 503
LEU A 538
ILE A 472
None
None
None
None
HG  A 909 (-3.6A)
1.08A 4km0B-4nhoA:
undetectable
4km0B-4nhoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
3 / 3 GLY A 527
PRO A 526
ALA A 475
SO4  A 902 (-3.3A)
SO4  A 902 ( 4.8A)
None
0.49A 4qn9B-4nhoA:
undetectable
4qn9B-4nhoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 6 ARG A 419
ILE A 422
GLN A 418
ILE A 379
None
1.20A 4z4dA-4nhoA:
undetectable
4z4dA-4nhoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
4 / 7 ALA A 801
VAL A 643
GLU A 794
HIS A 798
None
1.18A 5ecnA-4nhoA:
1.5
5ecnA-4nhoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.30A 5eeuH-4nhoA:
undetectable
5eeuI-4nhoA:
undetectable
5eeuH-4nhoA:
9.43
5eeuI-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.27A 5eeuJ-4nhoA:
undetectable
5eeuK-4nhoA:
undetectable
5eeuJ-4nhoA:
9.43
5eeuK-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.27A 5eevJ-4nhoA:
undetectable
5eevK-4nhoA:
undetectable
5eevJ-4nhoA:
9.43
5eevK-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.30A 5eewH-4nhoA:
undetectable
5eewI-4nhoA:
undetectable
5eewH-4nhoA:
9.43
5eewI-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.27A 5eewJ-4nhoA:
undetectable
5eewK-4nhoA:
undetectable
5eewJ-4nhoA:
9.43
5eewK-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.30A 5eexH-4nhoA:
undetectable
5eexI-4nhoA:
undetectable
5eexH-4nhoA:
9.43
5eexI-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5eexI-4nhoA:
undetectable
5eexJ-4nhoA:
undetectable
5eexI-4nhoA:
9.43
5eexJ-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.27A 5eexJ-4nhoA:
undetectable
5eexK-4nhoA:
undetectable
5eexJ-4nhoA:
9.43
5eexK-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.29A 5eeyI-4nhoA:
undetectable
5eeyJ-4nhoA:
undetectable
5eeyI-4nhoA:
9.43
5eeyJ-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 10 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.27A 5eeyJ-4nhoA:
undetectable
5eeyK-4nhoA:
undetectable
5eeyJ-4nhoA:
9.43
5eeyK-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5eezI-4nhoA:
undetectable
5eezJ-4nhoA:
undetectable
5eezI-4nhoA:
9.43
5eezJ-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5ef0I-4nhoA:
undetectable
5ef0J-4nhoA:
undetectable
5ef0I-4nhoA:
9.43
5ef0J-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5ef1I-4nhoA:
undetectable
5ef1J-4nhoA:
undetectable
5ef1I-4nhoA:
9.43
5ef1J-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5ef2I-4nhoA:
undetectable
5ef2J-4nhoA:
undetectable
5ef2I-4nhoA:
9.43
5ef2J-4nhoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo
sapiens)
5 / 11 ARG A 374
GLY A 433
ALA A 421
THR A 381
ILE A 431
None
1.28A 5ef3I-4nhoA:
undetectable
5ef3J-4nhoA:
undetectable
5ef3I-4nhoA:
9.43
5ef3J-4nhoA:
9.43