SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 LEU E 160
GLU E 163
ALA E 158
LEU E 130
 None
 1.09A 1eta1-4nhuE:
undetectable		 1eta1-4nhuE:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 LEU E 160
GLU E 163
ALA E 158
LEU E 130
 None
 1.13A 1eta2-4nhuE:
undetectable		 1eta2-4nhuE:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 6 LEU E 160
GLU E 163
ALA E 158
LEU E 130
 None
 1.08A 1etb1-4nhuE:
undetectable		 1etb1-4nhuE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 ALA E 152
TYR E 155
ALA E 200
GLN E  70
 None
 1.13A 1xl6A-4nhuE:
undetectable
1xl6B-4nhuE:
undetectable		 1xl6A-4nhuE:
21.50
1xl6B-4nhuE:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 ALA E 140
GLN E 141
ILE E 142
ARG E 145
 None
 1.45A 2z0aA-4nhuE:
undetectable		 2z0aA-4nhuE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 8 TYR E 123
TYR E  84
TYR E 118
HIS E  93
 None
 0.88A 2zm8A-4nhuE:
undetectable		 2zm8A-4nhuE:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 8 TYR E 123
TYR E  84
TYR E 118
HIS E  93
 None
 0.93A 2zmaA-4nhuE:
undetectable		 2zmaA-4nhuE:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		3 / 3 ARG E 170
GLU E 163
TYR E   7
 None
 0.83A 3k37B-4nhuE:
undetectable		 3k37B-4nhuE:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39A-4nhuE:
undetectable		 3k39A-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39C-4nhuE:
undetectable		 3k39C-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.50A 3k39F-4nhuE:
undetectable		 3k39F-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39G-4nhuE:
undetectable		 3k39G-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39H-4nhuE:
undetectable		 3k39H-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39I-4nhuE:
undetectable		 3k39I-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.47A 3k39J-4nhuE:
undetectable		 3k39J-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.46A 3k39L-4nhuE:
undetectable		 3k39L-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ARG E  97
GLU E 114
LEU E 126
ALA E 167
GLU E 163
 None
 1.48A 3k39M-4nhuE:
undetectable		 3k39M-4nhuE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 VAL E  25
VAL E  34
ARG E  35
LYS E  68
 None
 1.42A 3rv5A-4nhuE:
undetectable
3rv5B-4nhuE:
undetectable		 3rv5A-4nhuE:
16.85
3rv5B-4nhuE:
16.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 10 TYR E  99
TYR E 123
ILE E 124
TRP E 147
ILE E 203
 None
 0.61A 3vriA-4nhuE:
26.4
3vriC-4nhuE:
undetectable		 3vriA-4nhuE:
48.55
3vriC-4nhuE:
6.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 10 TYR E  99
TYR E 123
ILE E 124
TRP E 147
ILE E 203
 None
 1.21A 3vriA-4nhuE:
26.4
3vriC-4nhuE:
undetectable		 3vriA-4nhuE:
48.55
3vriC-4nhuE:
6.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 TYR E  99
TYR E 123
ILE E 124
TRP E 147
ILE E 203
 None
 0.62A 3vrjA-4nhuE:
26.5
3vrjC-4nhuE:
undetectable		 3vrjA-4nhuE:
48.55
3vrjC-4nhuE:
5.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 TYR E  99
TYR E 123
ILE E 124
TRP E 147
ILE E 203
 None
 1.22A 3vrjA-4nhuE:
26.5
3vrjC-4nhuE:
undetectable		 3vrjA-4nhuE:
48.55
3vrjC-4nhuE:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 TYR E 155
TYR E  99
GLU E   9
GLN E  70
 None
 1.39A 4qztB-4nhuE:
undetectable		 4qztB-4nhuE:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN
(Mus
musculus) 		5 / 10 LEU E  81
GLY E  83
TYR E  85
ALA E 140
ILE E 203
 None
 1.16A 4xj7C-4nhuE:
undetectable
4xj7D-4nhuE:
undetectable		 4xj7C-4nhuE:
21.94
4xj7D-4nhuE:
21.94