SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nhw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A  65
LEU A  62
THR A  74
VAL A  72
 None
GSH  A 301 (-3.7A)
None
None
 1.00A 1dvxB-4nhwA:
undetectable		 1dvxB-4nhwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A  84
LEU A  81
ALA A 170
LEU A 172
THR A 106
 None
 1.28A 1tz8A-4nhwA:
undetectable
1tz8B-4nhwA:
undetectable		 1tz8A-4nhwA:
21.74
1tz8B-4nhwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 PHE A 178
VAL A 194
TRP A 197
 None
 0.52A 2cc8A-4nhwA:
undetectable		 2cc8A-4nhwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 PHE A 178
VAL A 194
TRP A 197
 None
 0.51A 2ccbA-4nhwA:
undetectable		 2ccbA-4nhwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 PHE A 178
VAL A 194
TRP A 197
 None
 0.50A 2vx9A-4nhwA:
undetectable		 2vx9A-4nhwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A  65
LEU A  62
THR A  74
VAL A  72
 None
GSH  A 301 (-3.7A)
None
None
 0.99A 3d2tB-4nhwA:
undetectable		 3d2tB-4nhwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		3 / 3 ASP A 171
GLU A  98
SER A 203
 None
 0.77A 3p2kA-4nhwA:
undetectable		 3p2kA-4nhwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 6 ARG A  14
LEU A  62
PRO A  64
GLU A  75
SER A  76
 GSH  A 301 ( 4.9A)
GSH  A 301 (-3.7A)
GSH  A 301 (-4.2A)
GSH  A 301 (-3.0A)
GSH  A 301 (-2.5A)
 0.63A 3vlnA-4nhwA:
19.4		 3vlnA-4nhwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 4 ILE A  57
ASN A  58
ILE A  63
VAL A  31
 None
None
GSH  A 301 (-4.1A)
None
 1.20A 4uy87-4nhwA:
undetectable		 4uy87-4nhwA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 148
VAL A 113
LEU A 198
VAL A 177
TRP A 197
 None
 1.45A 5eb5B-4nhwA:
undetectable		 5eb5B-4nhwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  81
ASN A  80
ALA A 170
ALA A 109
ILE A 102
 None
 1.23A 5eypB-4nhwA:
undetectable		 5eypB-4nhwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  81
ASN A  80
ALA A 170
ALA A 109
ILE A 102
 None
 1.20A 5xiwD-4nhwA:
undetectable		 5xiwD-4nhwA:
14.17