SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		5 / 9 THR A 115
TYR A 179
LEU A 168
VAL A 211
LEU A 164
 None
 1.41A 2zb8A-4nhzA:
undetectable		 2zb8A-4nhzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 TYR A  96
ASP A  82
ASP A  76
 None
 0.85A 3r24A-4nhzA:
undetectable		 3r24A-4nhzA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		4 / 8 ALA A 213
THR A 209
ARG A 217
GLU A 165
 None
 0.96A 3rglA-4nhzA:
undetectable		 3rglA-4nhzA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
 GSH  A 301 (-3.5A)
GSH  A 301 ( 4.9A)
None
None
None
 0.55A 4mf6A-4nhzA:
36.6		 4mf6A-4nhzA:
74.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 ASP A 183
TYR A 179
TRP A 214
 None
 1.25A 4p7nA-4nhzA:
undetectable		 4p7nA-4nhzA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.90A 4z4fA-4nhzA:
undetectable		 4z4fA-4nhzA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		4 / 7 LEU A  23
PRO A 231
LEU A  38
GLU A  39
 None
 0.98A 5t7bA-4nhzA:
undetectable		 5t7bA-4nhzA:
14.99