SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ni2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 4 ILE B 562
MET B 503
VAL B 469
GLY B 522
 None
None
EDO  B 702 ( 4.5A)
None
 1.40A 1e06B-4ni2B:
undetectable		 1e06B-4ni2B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 LEU A 626
LEU A 554
PHE A 634
PHE A 656
ILE A 616
 None
 1.16A 1g5yC-4ni2A:
undetectable		 1g5yC-4ni2A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 SER B 435
ASN B 431
GLU B 554
LYS B 478
 None
None
EDO  B 703 (-2.9A)
EDO  B 703 ( 3.4A)
 1.16A 1mxgA-4ni2B:
undetectable		 1mxgA-4ni2B:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 9 TYR A 510
LEU A 506
VAL A 563
ILE A 575
PHE A 513
 None
EDO  A 702 ( 4.8A)
None
None
None
 1.21A 1q6iA-4ni2A:
undetectable		 1q6iA-4ni2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 9 TYR B 454
LEU B 450
VAL B 510
ILE B 521
PHE B 457
 None
 1.25A 1q6iA-4ni2B:
undetectable		 1q6iA-4ni2B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 9 TYR B 454
LEU B 450
VAL B 517
ILE B 521
PHE B 457
 None
None
EDO  B 704 ( 3.6A)
None
None
 0.96A 1q6iA-4ni2B:
undetectable		 1q6iA-4ni2B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		3 / 3 ALA B 493
THR B 525
PHE B 582
 None
 0.75A 2c6nB-4ni2B:
undetectable		 2c6nB-4ni2B:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 SER A 485
ALA A 531
ALA A 604
GLY A 576
TYR A 523
 None
EDO  A 702 (-3.5A)
None
None
None
 1.18A 2igtC-4ni2A:
undetectable		 2igtC-4ni2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 TYR B 454
VAL B 517
ILE B 521
PHE B 457
 None
EDO  B 704 ( 3.6A)
None
None
 0.59A 3uqbA-4ni2B:
undetectable		 3uqbA-4ni2B:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE B 543
GLY A 529
THR B 546
PHE A 490
 EDO  A 702 ( 4.3A)
EDO  B 701 ( 3.2A)
None
EDO  A 702 ( 3.0A)
 0.95A 3vnsA-4ni2B:
undetectable		 3vnsA-4ni2B:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 ILE B 519
LEU B 460
LEU B 453
ILE B 562
LEU B 423
 None
 0.92A 3vrmA-4ni2B:
undetectable		 3vrmA-4ni2B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		3 / 3 VAL B 564
SER B 565
THR B 568
 None
 0.48A 4luhA-4ni2B:
undetectable		 4luhA-4ni2B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 GLY B 526
VAL B 420
THR B 550
VAL B 528
LEU B 542
 None
None
None
None
EDO  B 701 ( 4.3A)
 1.28A 4yb6A-4ni2B:
3.8
4yb6E-4ni2B:
3.6		 4yb6A-4ni2B:
21.10
4yb6E-4ni2B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 GLY B 526
VAL B 420
THR B 550
VAL B 528
LEU B 542
 None
None
None
None
EDO  B 701 ( 4.3A)
 1.28A 4yb6C-4ni2B:
3.6
4yb6F-4ni2B:
3.5		 4yb6C-4ni2B:
21.10
4yb6F-4ni2B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 LEU B 542
GLY B 526
VAL B 420
THR B 550
VAL B 528
 EDO  B 701 ( 4.3A)
None
None
None
None
 1.29A 4yb6A-4ni2B:
3.8
4yb6D-4ni2B:
3.8		 4yb6A-4ni2B:
21.10
4yb6D-4ni2B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 LEU B 542
GLY B 526
VAL B 420
THR B 550
VAL B 528
 EDO  B 701 ( 4.3A)
None
None
None
None
 1.28A 4yb6B-4ni2B:
3.8
4yb6F-4ni2B:
3.5		 4yb6B-4ni2B:
21.10
4yb6F-4ni2B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		3 / 3 MET B 599
HIS B 524
GLY B 594
 None
 0.84A 5gwzB-4ni2B:
undetectable		 5gwzB-4ni2B:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 PHE B 457
TYR B 454
LEU B 453
ALA B 507
ILE B 427
 None
None
None
None
EDO  B 704 (-4.3A)
 0.95A 5h8tA-4ni2B:
undetectable		 5h8tA-4ni2B:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 6 PHE B 457
PHE B 468
SER B 425
ASP B 502
 None
 1.25A 5hesA-4ni2B:
undetectable		 5hesA-4ni2B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 ILE B 521
ILE A 528
TYR B 479
LEU B 499
 None
EDO  B 701 (-4.4A)
None
None
 0.91A 5ieoA-4ni2B:
undetectable		 5ieoA-4ni2B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
 1.17A 5lg3F-4ni2A:
undetectable		 5lg3F-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
 1.19A 5lg3G-4ni2A:
1.7		 5lg3G-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
 1.18A 5lg3H-4ni2A:
undetectable		 5lg3H-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
 1.15A 5lg3J-4ni2A:
undetectable		 5lg3J-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ASP A 486
PHE A 490
GLY B 544
GLY A 529
 EDO  A 702 (-3.7A)
EDO  A 702 ( 3.0A)
None
EDO  B 701 ( 3.2A)
 0.93A 5n9xA-4ni2A:
undetectable		 5n9xA-4ni2A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		3 / 3 VAL A 563
LYS A 555
MET A 552
 None
 1.06A 5nknA-4ni2A:
undetectable		 5nknA-4ni2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B 593
LYS A 606
SER A 609
 None
 1.20A 5odiA-4ni2B:
undetectable		 5odiA-4ni2B:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 VAL B 482
VAL B 472
ASP B 418
VAL B 529
TYR B 540
 None
EDO  B 701 ( 4.9A)
None
None
None
 1.48A 6iblA-4ni2B:
undetectable		 6iblA-4ni2B:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 VAL B 482
VAL B 472
ASP B 418
VAL B 529
TYR B 540
 None
EDO  B 701 ( 4.9A)
None
None
None
 1.45A 6iblB-4ni2B:
undetectable		 6iblB-4ni2B:
16.59