SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ni5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		7 / 11 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  61
VAL A  62
ALA A  89
 None
 0.41A 1uayA-4ni5A:
31.5		 1uayA-4ni5A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		7 / 10 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  61
VAL A  62
ALA A  89
 None
 0.37A 1uayB-4ni5A:
31.9		 1uayB-4ni5A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 GLY A  12
ASP A  36
ASP A  61
ASN A  88
ALA A  89
 None
 0.97A 2bm9E-4ni5A:
5.4		 2bm9E-4ni5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 VAL A  32
ILE A  34
GLY A  13
GLY A  18
ILE A  17
 None
 0.96A 2r5pA-4ni5A:
undetectable		 2r5pA-4ni5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 VAL A  32
ILE A  34
GLY A  13
GLY A  18
ILE A  17
 None
 0.96A 2r5pC-4ni5A:
undetectable		 2r5pC-4ni5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		3 / 3 ARG A 213
VAL A 221
THR A  21
 None
 0.78A 3cyxA-4ni5A:
undetectable		 3cyxA-4ni5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 GLY A  12
SER A  15
ASP A  36
PHE A  37
ASP A  61
 None
 1.28A 3iv6B-4ni5A:
5.9		 3iv6B-4ni5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 ASN A  88
THR A  60
VAL A  68
ILE A  72
ILE A   9
 None
 1.13A 3kpbA-4ni5A:
undetectable		 3kpbA-4ni5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 9 VAL A 178
ALA A 168
TYR A 171
GLY A 132
GLY A 172
 None
 1.31A 4mm5A-4ni5A:
undetectable		 4mm5A-4ni5A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 9 VAL A 178
ALA A 168
TYR A 171
GLY A 132
GLY A 172
 None
 1.28A 4mmbA-4ni5A:
undetectable		 4mmbA-4ni5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 9 ALA A  87
ILE A  17
GLY A  18
ILE A  34
ILE A 111
 None
 1.15A 4nptA-4ni5A:
undetectable		 4nptA-4ni5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 11 GLY A  12
GLY A  13
THR A  21
ASP A  36
ASP A  61
 None
 1.00A 4pghA-4ni5A:
5.4		 4pghA-4ni5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 GLY A  16
ALA A  20
PHE A  86
ASN A  88
VAL A 136
 None
 1.14A 6bqgA-4ni5A:
undetectable		 6bqgA-4ni5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 12 VAL A 217
ALA A  20
PHE A  86
ASN A  88
VAL A 136
 None
 1.05A 6drxA-4ni5A:
undetectable		 6drxA-4ni5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		4 / 5 ILE A 141
GLN A 246
THR A 244
LEU A 202
 None
 1.15A 6f3mD-4ni5A:
8.4		 6f3mD-4ni5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		4 / 5 ILE A 141
GLN A 246
THR A 244
LEU A 211
 None
 0.97A 6f3mD-4ni5A:
8.4		 6f3mD-4ni5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 11 ALA A 225
VAL A 136
VAL A  10
ILE A  17
ALA A  24
 None
 0.99A 6h1lB-4ni5A:
undetectable		 6h1lB-4ni5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Brucella
suis) 		5 / 11 HIS A 142
LEU A 211
HIS A 206
GLY A 184
SER A 140
 None
 1.23A 6ieyA-4ni5A:
5.5
6ieyB-4ni5A:
5.5		 6ieyA-4ni5A:
23.68
6ieyB-4ni5A:
23.68