SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		4 / 7 TYR B  97
TYR B 172
PRO B 180
TYR B 223
 None
 0.69A 2oldA-4nikB:
13.8
2oldB-4nikB:
14.0		 2oldA-4nikB:
28.37
2oldB-4nikB:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		4 / 7 TYR B 172
PRO B 180
TYR B 223
TYR B  97
 None
 0.62A 2oldA-4nikB:
13.8
2oldB-4nikB:
14.0		 2oldA-4nikB:
28.37
2oldB-4nikB:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		5 / 12 SER B 145
VAL B 144
PHE B 198
ILE B 211
HIS B 175
 None
 1.45A 2vdyB-4nikB:
undetectable		 2vdyB-4nikB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		4 / 6 TRP B  38
MET B  36
ARG B  74
THR B  78
 None
 1.44A 2x2iA-4nikB:
undetectable		 2x2iA-4nikB:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		5 / 10 TRP B  49
SER B  52
TYR B  61
GLY B 101
TRP B 109
 None
 1.02A 3ls4H-4nikB:
22.7		 3ls4H-4nikB:
45.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		6 / 12 VAL B   4
ALA B  26
MET B  36
ARG B  74
ASN B  76
TYR B 108
 None
 1.09A 3qxvA-4nikB:
20.3		 3qxvA-4nikB:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		5 / 9 LEU B 241
THR B 239
VAL B 144
ILE B 152
PHE B 198
 None
 1.04A 3tbgD-4nikB:
undetectable		 3tbgD-4nikB:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		6 / 7 TYR B 168
SER B 170
TYR B 172
TYR B 185
GLU B 186
PRO B 191
 None
 0.60A 5aclA-4nikB:
14.0		 5aclA-4nikB:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		4 / 8 THR B 153
SER B 199
ALA B 207
ASP B 187
 None
 0.97A 5l5fY-4nikB:
undetectable
5l5fZ-4nikB:
undetectable		 5l5fY-4nikB:
20.55
5l5fZ-4nikB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens) 		5 / 12 LEU B  83
VAL B  39
ASN B  37
ARG B 233
SER B  57
 None
 1.44A 5v1tA-4nikB:
undetectable		 5v1tA-4nikB:
19.48