SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 5 ASP A 582
LEU A 414
ALA A 526
LEU A 527
 None
 1.08A 1nh8A-4nj5A:
undetectable		 1nh8A-4nj5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 9 PHE A 548
VAL A 603
LEU A 620
MET A 581
LEU A 634
 None
 1.39A 1wrkA-4nj5A:
undetectable
1wrkB-4nj5A:
undetectable		 1wrkA-4nj5A:
9.82
1wrkB-4nj5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		3 / 3 PHE A 366
TYR A 382
TYR A 397
 None
 1.03A 1x70B-4nj5A:
undetectable		 1x70B-4nj5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 12 ALA A 295
VAL A 306
SER A 299
GLY A 292
ILE A 235
 None
 1.15A 2dcfA-4nj5A:
undetectable		 2dcfA-4nj5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 11 GLY A 291
PRO A 248
SER A 299
ASN A 293
TYR A 348
 None
 1.47A 2h21B-4nj5A:
4.7		 2h21B-4nj5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 11 GLY A 291
PRO A 248
SER A 299
ASN A 293
TYR A 348
 None
 1.43A 2h21C-4nj5A:
5.5		 2h21C-4nj5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 5 LEU A 222
LEU A 227
LEU A 328
MET A 359
 None
 1.12A 2oaxF-4nj5A:
undetectable		 2oaxF-4nj5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 12 PHE A 218
VAL A 318
THR A 461
LEU A 559
ALA A 186
 None
 1.46A 3apxA-4nj5A:
undetectable		 3apxA-4nj5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		3 / 3 TRP A 556
VAL A 224
ARG A 199
 None
 0.70A 3b0wA-4nj5A:
undetectable		 3b0wA-4nj5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 8 VAL A 224
VAL A 562
TYR A 155
ILE A 154
 None
 0.90A 3remA-4nj5A:
undetectable		 3remA-4nj5A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 6 MET A 153
GLY A 557
ARG A 149
GLU A 554
 None
 1.37A 4bqfA-4nj5A:
undetectable		 4bqfA-4nj5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		3 / 3 LYS A 150
ARG A 149
TRP A 553
 None
 1.19A 4i90A-4nj5A:
undetectable		 4i90A-4nj5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 6 GLU A 631
ARG A 508
GLU A 502
SER A 500
 None
 1.26A 4kr3A-4nj5A:
undetectable		 4kr3A-4nj5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 8 THR A 417
LEU A 620
VAL A 618
VAL A 583
 None
 1.16A 4l4dA-4nj5A:
undetectable		 4l4dA-4nj5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		3 / 3 ARG A 378
ASP A 401
ARG A 508
 None
 0.95A 4mx0A-4nj5A:
undetectable		 4mx0A-4nj5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 5 ILE A 207
VAL A 210
PHE A 217
CYH A 223
 None
 1.34A 4rzvA-4nj5A:
undetectable		 4rzvA-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 5 ILE A 203
PHE A 220
SER A 206
ASP A 236
 None
 1.01A 4rzvB-4nj5A:
undetectable		 4rzvB-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		4 / 6 TYR A 592
TYR A 636
GLY A 504
ASP A 403
 None
 1.32A 5emlA-4nj5A:
undetectable		 5emlA-4nj5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 12 GLY A 205
ASN A 198
GLY A 327
ARG A 310
SER A 252
 None
 1.13A 5hikA-4nj5A:
undetectable		 5hikA-4nj5A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9
(Arabidopsis
thaliana) 		5 / 12 GLY A 205
ASN A 198
GLY A 327
ASP A 326
ARG A 310
 None
 1.11A 5hikA-4nj5A:
undetectable		 5hikA-4nj5A:
19.04