SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4njz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A  56
LEU A  90
SER A 144
LEU A 158
LEU A 127
 None
None
SO4  A 201 (-2.8A)
None
None
 1.18A 2hc4A-4njzA:
undetectable		 2hc4A-4njzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A  60
ILE A  92
PHE A  56
LEU A  90
ASP A  80
 None
None
None
None
SO4  A 201 (-2.8A)
 1.22A 2q6hA-4njzA:
undetectable		 2q6hA-4njzA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		8 / 10 ILE A  55
PHE A  56
ILE A  59
ASP A  80
LEU A  90
SER A 144
HIS A 149
HIS A 151
 None
None
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-4.8A)
 0.59A 3o1cA-4njzA:
21.9		 3o1cA-4njzA:
47.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		8 / 10 ILE A  55
PHE A  56
ILE A  59
ASP A  80
LEU A  90
SER A 144
HIS A 149
HIS A 151
 None
None
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-4.8A)
 0.61A 3o1xA-4njzA:
21.8		 3o1xA-4njzA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		8 / 10 ILE A  55
PHE A  56
ILE A  59
ASP A  80
LEU A  90
SER A 144
HIS A 149
HIS A 151
 None
None
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-2.8A)
None
SO4  A 201 (-4.8A)
 0.66A 3qgzA-4njzA:
22.0		 3qgzA-4njzA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 8 GLN A  84
ASN A 136
ALA A 142
GLN A 143
HIS A 149
HIS A 151
 None
None
None
None
None
SO4  A 201 (-4.8A)
 0.25A 5km8A-4njzA:
19.7
5km8B-4njzA:
23.9		 5km8A-4njzA:
85.28
5km8B-4njzA:
85.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 8 GLN A  84
ASN A 136
ALA A 142
GLN A 143
SER A 144
HIS A 151
 None
None
None
None
SO4  A 201 (-2.8A)
SO4  A 201 (-4.8A)
 0.51A 5km8A-4njzA:
19.7
5km8B-4njzA:
23.9		 5km8A-4njzA:
85.28
5km8B-4njzA:
85.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		8 / 12 ILE A  55
PHE A  56
ILE A  59
LEU A  64
ASP A  80
VAL A  81
ALA A  82
LEU A  90
 None
None
None
None
SO4  A 201 (-2.8A)
None
SO4  A 201 ( 4.7A)
None
 0.39A 5km9B-4njzA:
23.8		 5km9B-4njzA:
85.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		10 / 12 PHE A  56
ILE A  59
LEU A  64
ASP A  80
VAL A  81
ALA A  82
LEU A  90
VAL A 145
HIS A 149
HIS A 151
 None
None
None
SO4  A 201 (-2.8A)
None
SO4  A 201 ( 4.7A)
None
None
None
SO4  A 201 (-4.8A)
 0.23A 5km9B-4njzA:
23.8		 5km9B-4njzA:
85.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 PHE A  56
ILE A  59
ASP A  80
LEU A  90
VAL A 145
HIS A 149
HIS A 151
 None
None
SO4  A 201 (-2.8A)
None
None
None
SO4  A 201 (-4.8A)
 0.32A 5uvmB-4njzA:
20.4		 5uvmB-4njzA:
30.81