SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.30A 3dqtA-4nk2A:
undetectable
3dqtB-4nk2A:
2.1		 3dqtA-4nk2A:
20.44
3dqtB-4nk2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.21A 3dqtA-4nk2A:
undetectable
3dqtB-4nk2A:
2.1		 3dqtA-4nk2A:
20.44
3dqtB-4nk2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		3 / 3 ASN A  73
HIS A  71
VAL A  94
 None
 0.90A 3elzB-4nk2A:
undetectable		 3elzB-4nk2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 0.97A 3n5pA-4nk2A:
1.6
3n5pB-4nk2A:
undetectable		 3n5pA-4nk2A:
19.40
3n5pB-4nk2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
PHE A 191
GLU A 186
 None
 1.24A 3n5tA-4nk2A:
1.4
3n5tB-4nk2A:
1.7		 3n5tA-4nk2A:
19.40
3n5tB-4nk2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
TRP A 159
GLU A 186
 None
 1.28A 3n5tA-4nk2A:
1.4
3n5tB-4nk2A:
1.7		 3n5tA-4nk2A:
19.40
3n5tB-4nk2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.19A 3n61A-4nk2A:
1.4
3n61B-4nk2A:
1.4		 3n61A-4nk2A:
20.05
3n61B-4nk2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.16A 3n61A-4nk2A:
1.4
3n61B-4nk2A:
1.4		 3n61A-4nk2A:
20.05
3n61B-4nk2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 TYR A 111
GLY A 116
THR A 112
LEU A 113
 HEM  A 700 (-4.5A)
None
None
None
 0.99A 3ps9A-4nk2A:
undetectable		 3ps9A-4nk2A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.32A 4k5jA-4nk2A:
undetectable
4k5jB-4nk2A:
undetectable		 4k5jA-4nk2A:
19.44
4k5jB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.28A 4k5jA-4nk2A:
undetectable
4k5jB-4nk2A:
undetectable		 4k5jA-4nk2A:
19.44
4k5jB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 0.97A 5addA-4nk2A:
1.4
5addB-4nk2A:
1.2		 5addA-4nk2A:
20.05
5addB-4nk2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 0.94A 5adeA-4nk2A:
1.4
5adeB-4nk2A:
undetectable		 5adeA-4nk2A:
20.05
5adeB-4nk2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.27A 5adlA-4nk2A:
undetectable
5adlB-4nk2A:
2.0		 5adlA-4nk2A:
19.44
5adlB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.19A 5adlA-4nk2A:
undetectable
5adlB-4nk2A:
2.0		 5adlA-4nk2A:
19.44
5adlB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 ALA A 144
VAL A 148
VAL A 101
HIS A  70
 None
 0.97A 5eclA-4nk2A:
undetectable		 5eclA-4nk2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.22A 5fj3A-4nk2A:
1.6
5fj3B-4nk2A:
2.1		 5fj3A-4nk2A:
19.44
5fj3B-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.16A 5fj3A-4nk2A:
1.6
5fj3B-4nk2A:
2.1		 5fj3A-4nk2A:
19.44
5fj3B-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.00A 5uo8C-4nk2A:
undetectable
5uo8D-4nk2A:
undetectable		 5uo8C-4nk2A:
18.22
5uo8D-4nk2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.00A 5uo9C-4nk2A:
undetectable
5uo9D-4nk2A:
undetectable		 5uo9C-4nk2A:
18.22
5uo9D-4nk2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.29A 5vv7A-4nk2A:
1.6
5vv7B-4nk2A:
2.1		 5vv7A-4nk2A:
19.44
5vv7B-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.22A 5vv7A-4nk2A:
1.6
5vv7B-4nk2A:
2.1		 5vv7A-4nk2A:
19.44
5vv7B-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.05A 5vvbA-4nk2A:
undetectable
5vvbB-4nk2A:
undetectable		 5vvbA-4nk2A:
18.22
5vvbB-4nk2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.24A 5vvnA-4nk2A:
undetectable
5vvnB-4nk2A:
undetectable		 5vvnA-4nk2A:
19.44
5vvnB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.18A 5vvnA-4nk2A:
undetectable
5vvnB-4nk2A:
undetectable		 5vvnA-4nk2A:
19.44
5vvnB-4nk2A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
PHE A 191
GLU A 186
 None
 1.18A 6av6A-4nk2A:
undetectable
6av6B-4nk2A:
undetectable		 6av6A-4nk2A:
19.13
6av6B-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
TRP A 159
GLU A 186
 None
 1.23A 6av6A-4nk2A:
undetectable
6av6B-4nk2A:
undetectable		 6av6A-4nk2A:
19.13
6av6B-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 GLU A 186
SER A 185
VAL A 182
TRP A 159
 None
 1.22A 6av6C-4nk2A:
undetectable
6av6D-4nk2A:
undetectable		 6av6C-4nk2A:
19.13
6av6D-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 PHE A 191
GLU A 186
SER A 185
VAL A 182
 None
 1.21A 6av6C-4nk2A:
undetectable
6av6D-4nk2A:
undetectable		 6av6C-4nk2A:
19.13
6av6D-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
PHE A 191
GLU A 186
 None
 1.16A 6av7A-4nk2A:
undetectable
6av7B-4nk2A:
undetectable		 6av7A-4nk2A:
19.13
6av7B-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 7 SER A 185
VAL A 182
TRP A 159
GLU A 186
 None
 1.22A 6av7A-4nk2A:
undetectable
6av7B-4nk2A:
undetectable		 6av7A-4nk2A:
19.13
6av7B-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.03A 6cifA-4nk2A:
undetectable
6cifB-4nk2A:
0.0		 6cifA-4nk2A:
19.13
6cifB-4nk2A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4nk2 HEMOGLOBIN-LIKE
PROTEIN
(Methylacidiphilu
m
infernorum) 		4 / 6 PHE A 191
GLU A 186
VAL A 182
TRP A 159
 None
 1.04A 6cifC-4nk2A:
0.0
6cifD-4nk2A:
undetectable		 6cifC-4nk2A:
19.13
6cifD-4nk2A:
19.13