SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 11 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.14A 1akdA-4nk7A:
undetectable		 1akdA-4nk7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 11 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.13A 1phgA-4nk7A:
undetectable		 1phgA-4nk7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 9 LEU A 409
VAL A 414
THR A 391
VAL A 495
VAL A 492
 None
 1.49A 2l8mA-4nk7A:
undetectable		 2l8mA-4nk7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 11 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.16A 3lxiB-4nk7A:
undetectable		 3lxiB-4nk7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 10 PRO A 461
ILE A 430
ILE A 433
VAL A 456
ILE A 405
 None
 1.15A 3p4wE-4nk7A:
undetectable		 3p4wE-4nk7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 9 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.14A 4c9kB-4nk7A:
undetectable		 4c9kB-4nk7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 10 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.14A 4jx1B-4nk7A:
undetectable		 4jx1B-4nk7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 9 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
 None
 1.16A 5cp4A-4nk7A:
undetectable		 5cp4A-4nk7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		3 / 3 HIS A 569
ASN A 572
ALA A 576
 None
 0.74A 5n4tB-4nk7A:
undetectable		 5n4tB-4nk7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Drosophila
melanogaster) 		5 / 12 GLN A 459
VAL A 456
GLU A 417
VAL A 415
GLU A 413
 None
 1.02A 6bzoC-4nk7A:
undetectable		 6bzoC-4nk7A:
11.30