SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		3 / 3 GLN A 257
ILE A 218
HIS A 217
 None
 0.73A 1fm9A-4nkhA:
undetectable		 1fm9A-4nkhA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		3 / 3 GLN A 257
ILE A 218
HIS A 217
 None
 0.73A 1k74A-4nkhA:
undetectable		 1k74A-4nkhA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 11 LEU A 279
LEU A 282
SER A 271
LEU A 272
LEU A 275
 None
 1.12A 2ceoA-4nkhA:
undetectable		 2ceoA-4nkhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 10 LEU A 238
LEU A 241
SER A 230
LEU A 231
LEU A 234
 None
 1.07A 2xn7A-4nkhA:
undetectable
2xn7B-4nkhA:
undetectable		 2xn7A-4nkhA:
22.22
2xn7B-4nkhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 11 GLU A 178
VAL A 202
LEU A 221
LEU A 228
THR A 209
 None
 1.13A 4lu3A-4nkhA:
undetectable		 4lu3A-4nkhA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 10 LEU A 279
LEU A 275
VAL A 304
LEU A 309
LEU A 312
 None
 1.19A 4po0A-4nkhA:
2.4		 4po0A-4nkhA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 10 SER A 251
LEU A 238
LEU A 221
LEU A 231
LEU A 214
 None
 1.19A 4yiaA-4nkhA:
undetectable		 4yiaA-4nkhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		4 / 7 VAL A 284
LEU A 289
ALA A 264
LEU A 279
 None
 0.55A 5jq7A-4nkhA:
undetectable		 5jq7A-4nkhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		4 / 7 VAL A 344
LEU A 349
ALA A 324
LEU A 339
 None
 0.59A 5jq7A-4nkhA:
undetectable		 5jq7A-4nkhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		6 / 11 LEU A 329
PRO A 333
SER A 311
LEU A 309
ARG A 303
ALA A 324
 None
 1.48A 5o96A-4nkhA:
undetectable
5o96B-4nkhA:
undetectable		 5o96A-4nkhA:
23.78
5o96B-4nkhA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		6 / 10 VAL A 284
LEU A 289
LEU A 309
LEU A 275
MET A 295
LEU A 272
 None
 1.24A 6f5uA-4nkhA:
undetectable
6f5uB-4nkhA:
undetectable		 6f5uA-4nkhA:
15.19
6f5uB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		5 / 10 VAL A 284
LEU A 289
LEU A 309
MET A 295
LEU A 272
 None
 0.84A 6f6nA-4nkhA:
undetectable
6f6nB-4nkhA:
undetectable		 6f6nA-4nkhA:
15.19
6f6nB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		4 / 6 VAL A 284
LEU A 289
LEU A 309
MET A 295
 None
 0.87A 6f6sA-4nkhA:
undetectable
6f6sB-4nkhA:
undetectable		 6f6sA-4nkhA:
15.19
6f6sB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		4 / 7 LEU A 252
LEU A 241
LEU A 238
LEU A 210
 None
 0.62A 6g9bA-4nkhA:
undetectable
6g9bB-4nkhA:
undetectable		 6g9bA-4nkhA:
15.19
6g9bB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1
(Salmonella
enterica) 		4 / 7 LEU A 272
LEU A 262
LEU A 259
LEU A 231
 None
 0.71A 6g9bA-4nkhA:
undetectable
6g9bB-4nkhA:
undetectable		 6g9bA-4nkhA:
15.19
6g9bB-4nkhA:
16.13