SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))
4nko ENGINEERED SCFV
HEAVY CHAIN
ENGINEERED SCFV
LIGHT CHAIN

(Mus
musculus)
5 / 12 TRP B  47
ALA B 107
PHE A  94
VAL A  99
PRO A 101
None
0.78A 1vpoH-4nkoB:
17.2
1vpoL-4nkoB:
13.5
1vpoH-4nkoB:
28.77
1vpoL-4nkoB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)
4nko ENGINEERED SCFV
LIGHT CHAIN

(Mus
musculus)
4 / 5 LEU A  78
GLY A  69
ILE A  53
PHE A  67
None
0.98A 1xf1A-4nkoA:
2.7
1xf1A-4nkoA:
9.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)
4nko ENGINEERED SCFV
HEAVY CHAIN
ENGINEERED SCFV
LIGHT CHAIN

(Mus
musculus)
5 / 10 HIS A  31
TYR A  37
PHE A  94
GLY A  96
TYR B  33
None
0.47A 2pcpC-4nkoA:
21.3
2pcpD-4nkoA:
14.8
2pcpC-4nkoA:
68.35
2pcpD-4nkoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)
4nko ENGINEERED SCFV
LIGHT CHAIN

(Mus
musculus)
3 / 3 MET A   4
GLU A  39
ASN A  58
None
1.01A 3a27A-4nkoA:
undetectable
3a27A-4nkoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUM_A_CCSA375_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus
musculus)
4 / 4 GLN B  39
SER B  92
GLY B  44
LYS B  43
None
1.41A 3rumA-4nkoB:
0.0
3rumA-4nkoB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus
musculus)
3 / 3 MET B  81
GLU B  82
LEU B  83
None
0.74A 4v2oB-4nkoB:
undetectable
4v2oB-4nkoB:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus
musculus)
4 / 7 ILE B  48
LEU B  70
GLY B  66
LYS B  65
None
0.93A 4z69A-4nkoB:
undetectable
4z69A-4nkoB:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus
musculus)
4 / 4 LEU B  45
GLY B  44
SER B  40
SER B  92
None
1.12A 5uunA-4nkoB:
undetectable
5uunA-4nkoB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus
musculus)
4 / 4 LEU B  45
GLY B  44
SER B  40
SER B  92
None
1.14A 5uunB-4nkoB:
undetectable
5uunB-4nkoB:
18.24