SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 7 ARG B 145
ILE B 144
LEU B 167
GLY B 166
 None
 0.83A 1rtsB-4nkqB:
undetectable		 1rtsB-4nkqB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_1
(SERINE/THREONINE
PHOSPHATASE B2
FK506-BINDING
PROTEIN)		 4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 4 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.28A 1tcoA-4nkqB:
0.0		 1tcoA-4nkqB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
(Homo
sapiens) 		4 / 7 ARG A 413
ARG A 415
GLN A 339
GLU A 427
 None
 1.04A 2c8aA-4nkqA:
undetectable		 2c8aA-4nkqA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 SER B 228
ASP B 231
ASP B 257
 None
 0.90A 3iv6A-4nkqB:
undetectable		 3iv6A-4nkqB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
(Homo
sapiens) 		4 / 8 ARG A 327
GLY A 275
PHE A 277
SER A 273
 None
 1.10A 3tzfB-4nkqA:
undetectable		 3tzfB-4nkqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4nkq GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 TRP B 287
SER B 288
PHE B 199
GLU B 197
 None
 1.27A 5b8iA-4nkqB:
undetectable		 5b8iA-4nkqB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
(Homo
sapiens) 		4 / 7 LEU A 222
ASP A 168
ARG A 221
GLN A 160
 None
 1.29A 6g31D-4nkqA:
undetectable		 6g31D-4nkqA:
9.56