SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 10 ALA H 359
GLU H 571
LEU H 621
ARG H 624
LEU H 220
 None
 1.42A 1a52A-4nl4H:
undetectable		 1a52A-4nl4H:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 12 ILE H 690
GLN H 693
THR H 707
ILE H 703
LEU H 669
 None
 1.18A 1dhfA-4nl4H:
2.2		 1dhfA-4nl4H:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 12 ILE H 690
GLN H 693
THR H 707
ILE H 703
LEU H 669
 None
 1.14A 1dhfB-4nl4H:
undetectable		 1dhfB-4nl4H:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 9 LEU H 541
GLY H 582
LEU H 555
LEU H 576
PHE H 423
 None
 1.14A 1nr6A-4nl4H:
undetectable		 1nr6A-4nl4H:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 10 ALA H 359
GLU H 571
LEU H 621
ARG H 624
LEU H 220
 None
 1.34A 1qkuA-4nl4H:
undetectable		 1qkuA-4nl4H:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 10 ALA H 359
GLU H 571
LEU H 621
ARG H 624
LEU H 220
 None
 1.34A 1qkuB-4nl4H:
undetectable		 1qkuB-4nl4H:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 10 ALA H 359
GLU H 571
LEU H 621
ARG H 624
LEU H 220
 None
 1.35A 1qkuC-4nl4H:
undetectable		 1qkuC-4nl4H:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		3 / 3 ASP H 323
LYS H 543
ARG H 583
 None
ADP  H 801 (-3.1A)
None
 1.10A 1ra8A-4nl4H:
undetectable		 1ra8A-4nl4H:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 8 THR H 308
PRO H 309
GLU H 273
ALA H 296
 None
 0.75A 2v32A-4nl4H:
undetectable
2v32B-4nl4H:
undetectable		 2v32A-4nl4H:
15.77
2v32B-4nl4H:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 8 THR H 308
PRO H 309
GLU H 273
ALA H 296
 None
 0.73A 2v32A-4nl4H:
undetectable
2v32B-4nl4H:
undetectable		 2v32A-4nl4H:
15.77
2v32B-4nl4H:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 8 THR H 308
PRO H 309
GLU H 273
ALA H 296
 None
 0.65A 2v41G-4nl4H:
undetectable
2v41H-4nl4H:
undetectable		 2v41G-4nl4H:
15.77
2v41H-4nl4H:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 4 ARG H 168
GLY H 171
GLU H 174
SER H 134
 None
 1.29A 2xctS-4nl4H:
3.4
2xctU-4nl4H:
3.7		 2xctS-4nl4H:
23.48
2xctU-4nl4H:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 11 LEU H 363
LEU H 360
GLU H 571
GLY H 354
LEU H 353
 None
 1.29A 3hm1B-4nl4H:
undetectable		 3hm1B-4nl4H:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 ASN H 160
ALA H 162
ALA H 163
LYS H 170
 None
 1.03A 3kp2B-4nl4H:
3.7		 3kp2B-4nl4H:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 8 ALA H 620
PHE H 573
ALA H 574
THR H 578
 None
 1.04A 3t3sE-4nl4H:
undetectable		 3t3sE-4nl4H:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 4 SER H 227
ASP H 319
ASP H 323
ALA H 356
 ADP  H 801 ( 3.7A)
None
None
None
 1.32A 3uj6A-4nl4H:
2.2		 3uj6A-4nl4H:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 12 LEU H 724
GLN H 693
THR H 707
ILE H 703
LEU H 669
 None
 1.12A 4kebB-4nl4H:
undetectable		 4kebB-4nl4H:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 11 THR H 538
LEU H 541
ILE H 536
SER H 507
PHE H 423
 None
 1.44A 4lhmA-4nl4H:
undetectable		 4lhmA-4nl4H:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 11 ILE H 534
LEU H 402
LEU H 500
ALA H 400
LEU H 493
 None
 0.97A 4p65E-4nl4H:
undetectable
4p65F-4nl4H:
undetectable
4p65J-4nl4H:
undetectable
4p65L-4nl4H:
undetectable		 4p65E-4nl4H:
2.49
4p65F-4nl4H:
3.76
4p65J-4nl4H:
3.76
4p65L-4nl4H:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 PHE H  16
PRO H   9
VAL H  10
ALA H   7
 None
 1.33A 4w5oA-4nl4H:
undetectable		 4w5oA-4nl4H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 ARG H 168
GLY H 171
GLU H 174
SER H 134
 None
 1.05A 4z3oA-4nl4H:
4.1
4z3oB-4nl4H:
3.9		 4z3oA-4nl4H:
23.09
4z3oB-4nl4H:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 PHE H  16
PRO H   9
VAL H  10
ALA H   7
 None
 1.33A 4z4cA-4nl4H:
2.1		 4z4cA-4nl4H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 PHE H  16
PRO H   9
VAL H  10
ALA H   7
 None
 1.33A 4z4dA-4nl4H:
undetectable		 4z4dA-4nl4H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 PHE H  16
PRO H   9
VAL H  10
ALA H   7
 None
 1.31A 4z4eA-4nl4H:
2.3		 4z4eA-4nl4H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 6 ILE H 534
LEU H 497
PHE H 501
ARG H 409
 None
 1.02A 5b1aN-4nl4H:
undetectable
5b1aW-4nl4H:
undetectable		 5b1aN-4nl4H:
20.03
5b1aW-4nl4H:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 SER H 134
ARG H 168
GLY H 171
GLU H 174
 None
 1.05A 5btiA-4nl4H:
3.7
5btiB-4nl4H:
undetectable		 5btiA-4nl4H:
22.99
5btiB-4nl4H:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 SER H 134
ARG H 168
GLY H 171
GLU H 174
 None
 1.12A 5btiC-4nl4H:
3.6
5btiD-4nl4H:
undetectable		 5btiC-4nl4H:
22.99
5btiD-4nl4H:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 SER H 134
ARG H 168
GLY H 171
GLU H 174
 None
 0.82A 5cdqA-4nl4H:
3.8
5cdqB-4nl4H:
undetectable
5cdqC-4nl4H:
3.4		 5cdqA-4nl4H:
21.76
5cdqB-4nl4H:
14.66
5cdqC-4nl4H:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		4 / 5 SER H 134
ARG H 168
GLY H 171
GLU H 174
 None
 0.83A 5cdqR-4nl4H:
undetectable
5cdqS-4nl4H:
undetectable
5cdqT-4nl4H:
undetectable		 5cdqR-4nl4H:
21.76
5cdqS-4nl4H:
14.66
5cdqT-4nl4H:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA
(Klebsiella
pneumoniae) 		5 / 11 ILE H 534
LEU H 535
THR H 538
LEU H 556
PHE H 423
 None
 1.43A 6hupA-4nl4H:
undetectable
6hupB-4nl4H:
undetectable		 6hupA-4nl4H:
6.71
6hupB-4nl4H:
6.72