SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 PHE A 195
TYR A 340
PRO A 197
 None
 1.17A 1mcnA-4nlbA:
undetectable
1mcnB-4nlbA:
undetectable
1mcnP-4nlbA:
undetectable		 1mcnA-4nlbA:
23.38
1mcnB-4nlbA:
23.38
1mcnP-4nlbA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 12 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.19A 1q23B-4nlbA:
undetectable		 1q23B-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 11 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.15A 1q23J-4nlbA:
undetectable		 1q23J-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 11 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.18A 1q23L-4nlbA:
undetectable		 1q23L-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 ILE A 473
SER A 499
SER A 495
 None
 0.59A 3iltH-4nlbA:
undetectable		 3iltH-4nlbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		4 / 4 VAL A 330
PHE A 323
PHE A 345
VAL A 428
 None
 1.37A 3rv5C-4nlbA:
undetectable
3rv5D-4nlbA:
undetectable		 3rv5C-4nlbA:
14.06
3rv5D-4nlbA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 12 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.17A 3u9fB-4nlbA:
undetectable
3u9fC-4nlbA:
undetectable		 3u9fB-4nlbA:
21.49
3u9fC-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 PHE A 283
CYH A 285
HIS A 275
 None
 1.09A 3u9fF-4nlbA:
undetectable		 3u9fF-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 12 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.15A 3u9fH-4nlbA:
undetectable
3u9fI-4nlbA:
undetectable		 3u9fH-4nlbA:
21.49
3u9fI-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 PHE A 283
CYH A 285
HIS A 275
 None
 1.03A 3u9fG-4nlbA:
undetectable		 3u9fG-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 12 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.14A 3u9fJ-4nlbA:
undetectable
3u9fK-4nlbA:
undetectable		 3u9fJ-4nlbA:
21.49
3u9fK-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		5 / 10 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.12A 3u9fK-4nlbA:
undetectable		 3u9fK-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 PHE A 283
CYH A 285
HIS A 275
 None
 1.01A 3u9fL-4nlbA:
undetectable		 3u9fL-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 PHE A 283
CYH A 285
HIS A 275
 None
 1.11A 3u9fS-4nlbA:
undetectable		 3u9fS-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6
(Trypanosoma
brucei) 		3 / 3 ALA A 350
ASN A 353
LEU A 354
 None
 0.39A 5i1pA-4nlbA:
undetectable		 5i1pA-4nlbA:
9.09