SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 349
ILE A 338
TYR A 468
VAL A 294
 None
 1.03A 1db1A-4nleA:
undetectable		 1db1A-4nleA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TYR A 468
HIS A 124
GLU A 343
LEU A 120
 None
 1.05A 1j96B-4nleA:
undetectable		 1j96B-4nleA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 9 ILE A 259
ARG A 161
ALA A 354
VAL A 268
 None
 0.86A 2vufA-4nleA:
undetectable		 2vufA-4nleA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ARG A 131
VAL A 455
LEU A 458
ALA A 465
ALA A 466
 None
 1.30A 3ax7B-4nleA:
undetectable		 3ax7B-4nleA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 184
VAL A 225
THR A 101
GLY A 190
 None
 1.21A 3elzB-4nleA:
undetectable		 3elzB-4nleA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 134
THR A 469
ALA A 130
ALA A 127
 None
 1.23A 3ns1C-4nleA:
undetectable		 3ns1C-4nleA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 131
LEU A 458
ALA A 465
ALA A 466
 None
 0.92A 3ns1L-4nleA:
undetectable		 3ns1L-4nleA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 136
ALA A 165
ALA A 166
MET A 255
 None
 0.70A 3r9tA-4nleA:
undetectable		 3r9tA-4nleA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 389
ILE A 393
LEU A 423
ALA A 378
 None
 0.74A 3r9tA-4nleA:
undetectable		 3r9tA-4nleA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 GLY A  99
GLY A 190
ARG A 186
LEU A 220
VAL A  38
ALA A  37
 None
 1.25A 3t7vA-4nleA:
undetectable		 3t7vA-4nleA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 263
HIS A 265
LEU A 261
TYR A 139
LEU A 349
 None
 1.32A 3tm4A-4nleA:
undetectable		 3tm4A-4nleA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 263
HIS A 265
LEU A 261
TYR A 139
LEU A 349
 None
 1.30A 3tm4B-4nleA:
undetectable		 3tm4B-4nleA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A 345
GLY A 249
PHE A 248
SER A 253
 None
 1.00A 3tzfB-4nleA:
undetectable		 3tzfB-4nleA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 MET A 262
LEU A 267
GLN A 360
PRO A 356
 None
 1.37A 3vkxA-4nleA:
undetectable		 3vkxA-4nleA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 249
PHE A 248
VAL A 129
GLY A 125
ARG A 461
 None
 1.17A 4acaB-4nleA:
undetectable
4acaC-4nleA:
undetectable		 4acaB-4nleA:
23.20
4acaC-4nleA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 423
PRO A 424
LEU A 425
ILE A 375
 None
 0.93A 4f4dB-4nleA:
undetectable		 4f4dB-4nleA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TYR A 366
HIS A 265
ARG A 147
 None
 0.98A 4htfA-4nleA:
undetectable		 4htfA-4nleA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A 162
THR A 258
VAL A 268
VAL A 348
 None
 1.17A 4l4dA-4nleA:
undetectable		 4l4dA-4nleA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A 251
PRO A 252
GLN A 298
 None
 0.55A 4oltB-4nleA:
0.9		 4oltB-4nleA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLU A 362
LEU A 267
ARG A 147
HIS A 284
 None
 1.14A 5dxeA-4nleA:
0.8		 5dxeA-4nleA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 336
GLY A 340
THR A 342
VAL A 300
LEU A 301
 None
 1.15A 5kocB-4nleA:
undetectable		 5kocB-4nleA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A 391
HIS A 390
ARG A 386
 None
 0.74A 5uunA-4nleA:
2.2		 5uunA-4nleA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLU A 362
LEU A 267
ARG A 147
HIS A 284
 None
 1.16A 6cbzA-4nleA:
2.8		 6cbzA-4nleA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 122
VAL A 459
LEU A 170
LEU A 173
 None
 0.88A 6e43D-4nleA:
2.6		 6e43D-4nleA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 VAL A 455
PRO A 252
MET A 255
VAL A 348
 None
 0.76A 6ekzA-4nleA:
undetectable		 6ekzA-4nleA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 302
ALA A 305
GLN A 341
ILE A 338
 None
 0.79A 6g9bA-4nleA:
undetectable
6g9bB-4nleA:
undetectable		 6g9bA-4nleA:
10.66
6g9bB-4nleA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4nle ADENYLOSUCCINATE
LYASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 237
THR A 223
TYR A 183
ALA A 244
LEU A 118
 None
 1.12A 6ie8A-4nleA:
2.1		 6ie8A-4nleA:
17.98