SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 VAL A 938
ARG A 933
ILE A 943
GLY A 919
 EDO  A1104 (-4.7A)
None
None
None
 0.96A 11gsA-4nmeA:
undetectable		 11gsA-4nmeA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.82A 1av2A-4nmeA:
undetectable
1av2B-4nmeA:
undetectable		 1av2A-4nmeA:
2.23
1av2B-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.84A 1av2C-4nmeA:
undetectable
1av2D-4nmeA:
undetectable		 1av2C-4nmeA:
2.23
1av2D-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 GLU A 346
ARG A 342
LEU A 373
GLU A 372
 None
 0.92A 1cmaA-4nmeA:
undetectable
1cmaB-4nmeA:
undetectable		 1cmaA-4nmeA:
7.96
1cmaB-4nmeA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 5 GLU A 381
ARG A 136
ASP A 191
LEU A 190
 None
 1.08A 1n13B-4nmeA:
undetectable
1n13C-4nmeA:
undetectable		 1n13B-4nmeA:
6.77
1n13C-4nmeA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 ASP A 191
LEU A 190
GLU A 381
ARG A 136
 None
 1.03A 1n13I-4nmeA:
undetectable
1n13L-4nmeA:
undetectable		 1n13I-4nmeA:
4.57
1n13L-4nmeA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 0.95A 1s9pA-4nmeA:
undetectable		 1s9pA-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 0.91A 1s9pC-4nmeA:
undetectable		 1s9pC-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 275
LEU A 304
ALA A 356
VAL A 366
ILE A 273
 None
None
P5F  A1101 ( 3.7A)
None
None
 1.01A 1s9pD-4nmeA:
undetectable		 1s9pD-4nmeA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 5 LYS A 203
ALA A 308
TYR A 418
ARG A 422
 P5F  A1101 (-1.3A)
P5F  A1101 (-3.2A)
None
None
 0.94A 1tj2A-4nmeA:
39.4		 1tj2A-4nmeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.84A 1w5uA-4nmeA:
undetectable
1w5uB-4nmeA:
undetectable		 1w5uA-4nmeA:
2.23
1w5uB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.76A 1w5uA-4nmeA:
undetectable
1w5uB-4nmeA:
undetectable		 1w5uA-4nmeA:
2.23
1w5uB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A 706
ASN A 705
GLU A 701
GLY A 702
 None
None
None
EDO  A1107 (-4.3A)
 1.00A 1ykiA-4nmeA:
undetectable
1ykiB-4nmeA:
undetectable		 1ykiA-4nmeA:
12.71
1ykiB-4nmeA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A 706
ASN A 705
GLU A 701
GLY A 702
 None
None
None
EDO  A1107 (-4.3A)
 1.00A 1ykiA-4nmeA:
undetectable
1ykiB-4nmeA:
undetectable		 1ykiA-4nmeA:
12.71
1ykiB-4nmeA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A 706
ASN A 705
GLU A 701
GLY A 702
 None
None
None
EDO  A1107 (-4.3A)
 1.01A 1ykiC-4nmeA:
undetectable
1ykiD-4nmeA:
undetectable		 1ykiC-4nmeA:
12.71
1ykiD-4nmeA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A 706
ASN A 705
GLU A 701
GLY A 702
 None
None
None
EDO  A1107 (-4.3A)
 1.00A 1ykiC-4nmeA:
undetectable
1ykiD-4nmeA:
undetectable		 1ykiC-4nmeA:
12.71
1ykiD-4nmeA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 PRO A 893
PRO A 864
TYR A 859
TYR A 831
LEU A 782
 None
 1.42A 1z9hA-4nmeA:
undetectable		 1z9hA-4nmeA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 PRO A 893
PRO A 864
TYR A 859
TYR A 831
LEU A 782
 None
 1.42A 1z9hB-4nmeA:
undetectable		 1z9hB-4nmeA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 PRO A 893
PRO A 864
TYR A 859
TYR A 831
LEU A 782
 None
 1.42A 1z9hC-4nmeA:
undetectable		 1z9hC-4nmeA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 ARG A 954
ASN A 320
ASP A 321
GLY A 949
 None
 1.06A 2f6dA-4nmeA:
undetectable		 2f6dA-4nmeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 4 THR A 205
THR A 151
ASP A 775
ASP A  57
 None
 1.46A 2f8lA-4nmeA:
undetectable		 2f8lA-4nmeA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 VAL A 938
ARG A 933
ILE A 943
GLY A 919
 EDO  A1104 (-4.7A)
None
None
None
 0.91A 2gssA-4nmeA:
undetectable		 2gssA-4nmeA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 VAL A 938
ARG A 933
ILE A 943
GLY A 919
 EDO  A1104 (-4.7A)
None
None
None
 0.91A 2gssB-4nmeA:
undetectable		 2gssB-4nmeA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ALA A 277
VAL A 326
TRP A 310
 None
None
P5F  A1101 (-3.6A)
 0.85A 2izqA-4nmeA:
undetectable
2izqB-4nmeA:
undetectable		 2izqA-4nmeA:
2.23
2izqB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.87A 2izqC-4nmeA:
undetectable
2izqD-4nmeA:
undetectable		 2izqC-4nmeA:
2.23
2izqD-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 6 SER A 923
LEU A 929
ASP A 770
GLU A  74
 None
 1.23A 2j2pE-4nmeA:
undetectable
2j2pF-4nmeA:
undetectable		 2j2pE-4nmeA:
12.20
2j2pF-4nmeA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 6 THR A 205
THR A 151
ASP A 775
ASP A  57
 None
 1.33A 2okcA-4nmeA:
undetectable		 2okcA-4nmeA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 ALA A 649
ALA A 728
SER A 758
GLY A 736
 None
 0.88A 2vh3B-4nmeA:
undetectable		 2vh3B-4nmeA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 TRP A 654
SER A 794
CYH A 793
GLN A 789
 None
 1.30A 2xz5A-4nmeA:
undetectable
2xz5B-4nmeA:
undetectable		 2xz5A-4nmeA:
11.34
2xz5B-4nmeA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 PHE A 957
LEU A 917
GLY A 966
GLY A 959
PHE A 915
 None
 1.06A 3dh0B-4nmeA:
4.6		 3dh0B-4nmeA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 GLN A 599
GLY A 790
GLY A 787
GLU A 889
 None
 0.80A 3fpjB-4nmeA:
5.8		 3fpjB-4nmeA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 6 GLN A 592
LEU A 594
GLU A 595
LEU A 537
 None
 0.90A 3h5gA-4nmeA:
undetectable
3h5gC-4nmeA:
undetectable		 3h5gA-4nmeA:
2.76
3h5gC-4nmeA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 6 LEU A 537
GLN A 592
LEU A 594
GLU A 595
 None
 0.97A 3h5gB-4nmeA:
undetectable
3h5gC-4nmeA:
undetectable		 3h5gB-4nmeA:
2.76
3h5gC-4nmeA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 SER A 247
ASP A 244
ASP A 775
TYR A 160
 None
P5F  A1101 (-3.2A)
None
None
 1.18A 3havA-4nmeA:
undetectable		 3havA-4nmeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.98A 3l8lA-4nmeA:
undetectable
3l8lB-4nmeA:
undetectable		 3l8lA-4nmeA:
2.23
3l8lB-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TRP A 310
ALA A 277
VAL A 326
 P5F  A1101 (-3.6A)
None
None
 0.84A 3l8lC-4nmeA:
undetectable
3l8lD-4nmeA:
undetectable		 3l8lC-4nmeA:
2.23
3l8lD-4nmeA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 261
TYR A 268
PHE A 240
LEU A 241
GLU A 264
 None
 1.27A 3medA-4nmeA:
2.2
3medB-4nmeA:
2.4		 3medA-4nmeA:
19.53
3medB-4nmeA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 VAL A 938
ARG A 933
ILE A 943
GLY A 919
 EDO  A1104 (-4.7A)
None
None
None
 0.92A 3n9jA-4nmeA:
undetectable		 3n9jA-4nmeA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 TYR A 831
ASP A 601
ASP A 606
 None
 0.54A 3ou6B-4nmeA:
3.7		 3ou6B-4nmeA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 PHE A 677
LEU A 693
LEU A 690
ALA A 578
ALA A 581
 None
 1.04A 3vw7A-4nmeA:
undetectable		 3vw7A-4nmeA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 SER A 925
VAL A  58
TYR A  75
ARG A  54
 None
 1.03A 4ijiH-4nmeA:
undetectable		 4ijiH-4nmeA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 MET A 816
ALA A 817
MET A 873
THR A 948
 None
 0.92A 4ltwA-4nmeA:
undetectable		 4ltwA-4nmeA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		6 / 10 ALA A 555
ALA A 557
ALA A 554
VAL A 676
GLY A 646
ASP A 723
 None
 1.43A 4qvyK-4nmeA:
undetectable
4qvyL-4nmeA:
undetectable		 4qvyK-4nmeA:
11.34
4qvyL-4nmeA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 PHE A 809
THR A 948
LEU A 895
 None
 0.79A 4qztA-4nmeA:
undetectable		 4qztA-4nmeA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 SER A 843
GLY A 731
SER A 732
GLU A 734
ALA A 652
 None
 1.16A 4u95B-4nmeA:
undetectable		 4u95B-4nmeA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 PRO A 204
GLU A 246
SER A 219
ASP A 827
 None
 0.93A 4uacA-4nmeA:
undetectable		 4uacA-4nmeA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 7 PRO A 657
SER A 684
ASP A 523
THR A 521
 None
 1.10A 4uacA-4nmeA:
undetectable		 4uacA-4nmeA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 12 LEU A 975
THR A 730
ALA A 728
ALA A 648
ILE A 757
 None
 1.10A 4x1kD-4nmeA:
undetectable		 4x1kD-4nmeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ASP A 187
ARG A 404
ARG A 136
 None
 0.92A 4x5iA-4nmeA:
undetectable		 4x5iA-4nmeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A  17
ARG A 361
ALA A 365
GLY A  14
 None
 0.86A 4xk8a-4nmeA:
undetectable		 4xk8a-4nmeA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 5 ALA A 331
ARG A 456
ALA A 451
GLU A 448
 None
 1.34A 5a06C-4nmeA:
4.9
5a06D-4nmeA:
2.4		 5a06C-4nmeA:
16.31
5a06D-4nmeA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		4 / 8 PHE A 586
ALA A 590
LEU A 588
LEU A 585
 None
 1.06A 5dzkd-4nmeA:
2.7
5dzkr-4nmeA:
undetectable		 5dzkd-4nmeA:
13.76
5dzkr-4nmeA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ASP A 187
ARG A 404
ARG A 136
 None
 0.88A 5eajB-4nmeA:
undetectable		 5eajB-4nmeA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 9 SER A 843
GLY A 731
SER A 732
GLU A 734
ALA A 652
 None
 1.24A 5entC-4nmeA:
undetectable		 5entC-4nmeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 6 MET A 898
ALA A 896
LEU A 895
ILE A 875
TYR A 806
 None
 1.14A 5mvmB-4nmeA:
undetectable
5mvmC-4nmeA:
undetectable		 5mvmB-4nmeA:
5.65
5mvmC-4nmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 VAL A 630
TYR A 640
GLN A 628
 None
 0.75A 5qgrA-4nmeA:
undetectable		 5qgrA-4nmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 VAL A 630
TYR A 640
GLN A 628
 None
 0.76A 5qgtA-4nmeA:
undetectable		 5qgtA-4nmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ARG A 568
PHE A 478
LEU A 575
 None
EDO  A1109 (-4.5A)
None
 0.91A 5x1bC-4nmeA:
undetectable		 5x1bC-4nmeA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 MET A 245
ASP A 285
ARG A 492
 None
 1.07A 5z6jA-4nmeA:
undetectable		 5z6jA-4nmeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 9 ILE A 396
ARG A 404
ALA A 141
LEU A 405
ALA A 407
 None
 1.32A 5zgbB-4nmeA:
1.6		 5zgbB-4nmeA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		5 / 9 ILE A 396
ARG A 404
ALA A 141
LEU A 405
ALA A 407
 None
 1.28A 5zghB-4nmeA:
0.0		 5zghB-4nmeA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		6 / 12 TYR A 974
PHE A 978
ILE A 757
TYR A 617
LEU A 726
ALA A 665
 None
 1.38A 5zwrA-4nmeA:
undetectable		 5zwrA-4nmeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		6 / 12 TYR A 974
PHE A 978
ILE A 757
TYR A 617
LEU A 726
ALA A 665
 None
 1.35A 5zwrB-4nmeA:
undetectable		 5zwrB-4nmeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 PHE A 486
ARG A 249
GLN A 214
 None
 1.01A 6g1pB-4nmeA:
undetectable		 6g1pB-4nmeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Geobacter
sulfurreducens) 		3 / 3 ASP A 187
LEU A 190
ARG A 136
 None
 0.80A 7dfrA-4nmeA:
undetectable		 7dfrA-4nmeA:
9.99