SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 12 GLY A 139
THR A 138
LEU A 236
THR A 212
LEU A 216
 None
 0.86A 1jipA-4nmlA:
undetectable		 1jipA-4nmlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 12 ALA A  86
THR A  58
TYR A  19
ALA A  15
ASP A  88
 None
 1.14A 1nt2A-4nmlA:
3.0		 1nt2A-4nmlA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 12 ILE A 135
ASP A  91
ALA A  90
GLY A 233
GLY A 103
 None
MLT  A 303 (-4.5A)
None
None
CL  A 301 (-3.5A)
 1.04A 1rjdA-4nmlA:
undetectable		 1rjdA-4nmlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 12 ILE A 135
ASP A  91
ALA A  90
GLY A 233
GLY A 103
 None
MLT  A 303 (-4.5A)
None
None
CL  A 301 (-3.5A)
 1.02A 1rjdB-4nmlA:
undetectable		 1rjdB-4nmlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 12 ILE A 135
ASP A  91
ALA A  90
GLY A 233
GLY A 103
 None
MLT  A 303 (-4.5A)
None
None
CL  A 301 (-3.5A)
 1.03A 1rjdC-4nmlA:
undetectable		 1rjdC-4nmlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 5 SER A  59
GLU A 111
THR A  62
ASP A  88
 None
CL  A 301 (-3.1A)
None
None
 1.19A 3zs3A-4nmlA:
undetectable		 3zs3A-4nmlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 9 ASP A  91
ALA A 239
GLY A 233
PHE A 235
GLY A  99
 MLT  A 303 (-4.5A)
None
None
None
None
 1.21A 4mmeB-4nmlA:
undetectable		 4mmeB-4nmlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 9 ASP A  91
ALA A 239
GLY A 233
PHE A 235
GLY A  99
 MLT  A 303 (-4.5A)
None
None
None
None
 1.17A 4mmfB-4nmlA:
undetectable		 4mmfB-4nmlA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		4 / 6 LEU A  28
MET A  45
LEU A  53
ILE A  79
 None
 0.99A 4okxA-4nmlA:
undetectable		 4okxA-4nmlA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 9 ASP A  91
ALA A 239
GLY A 233
PHE A 235
GLY A  99
 MLT  A 303 (-4.5A)
None
None
None
None
 1.15A 6awoA-4nmlA:
undetectable		 6awoA-4nmlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nml RIBULOSE 5-PHOSPHATE
ISOMERASE
(Toxoplasma
gondii) 		5 / 9 ASP A  91
ALA A 239
GLY A 233
PHE A 235
GLY A  99
 MLT  A 303 (-4.5A)
None
None
None
None
 1.16A 6awqA-4nmlA:
undetectable		 6awqA-4nmlA:
20.25