SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 GLU A  26
ASN A  61
TRP A  56
 None
 1.26A 1r15C-4nmnA:
undetectable		 1r15C-4nmnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 GLU A  26
ASN A  61
TRP A  56
 None
 1.26A 1r15D-4nmnA:
undetectable		 1r15D-4nmnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 GLU A  26
ASN A  61
TRP A  56
 None
 1.27A 1r15E-4nmnA:
undetectable		 1r15E-4nmnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 GLU A  26
ASN A  61
TRP A  56
 None
 1.24A 1r15F-4nmnA:
undetectable		 1r15F-4nmnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 PRO A 290
ASP A 287
ASP A 296
 None
 0.80A 1sqfA-4nmnA:
undetectable		 1sqfA-4nmnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		4 / 7 LEU A 391
PHE A 196
MET A 353
VAL A 352
 None
 1.05A 1wrlA-4nmnA:
undetectable
1wrlB-4nmnA:
undetectable		 1wrlA-4nmnA:
16.67
1wrlB-4nmnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 LEU A 189
ILE A 413
ILE A 412
ARG A 369
LEU A 387
 None
 1.07A 1xdkB-4nmnA:
undetectable		 1xdkB-4nmnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 LEU A 426
PHE A 186
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.75A 1xdkF-4nmnA:
undetectable		 1xdkF-4nmnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 10 LEU A 217
LEU A 243
LEU A 286
ILE A 284
ALA A 314
 None
 1.09A 2bxeB-4nmnA:
undetectable		 2bxeB-4nmnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 LEU A 217
LEU A 243
LEU A 286
ILE A 284
ALA A 314
 None
 1.02A 2bxpA-4nmnA:
undetectable		 2bxpA-4nmnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 ILE A 219
VAL A 411
LEU A 391
ALA A 436
MET A 250
 None
 1.49A 2jj8C-4nmnA:
2.8		 2jj8C-4nmnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		4 / 5 PRO A 290
ALA A 291
ASP A 287
ASP A 296
 None
 0.90A 2nyuB-4nmnA:
3.3		 2nyuB-4nmnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 ASP A 386
HIS A 197
GLY A 199
LEU A 182
GLY A 195
 None
 1.05A 4blvB-4nmnA:
5.8		 4blvB-4nmnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 LEU A 201
LEU A 341
LEU A 297
ILE A 203
ARG A 330
 None
 1.21A 4f4dA-4nmnA:
undetectable		 4f4dA-4nmnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 11 ILE A 412
LEU A 372
PHE A 390
LEU A 358
THR A 421
 None
 1.40A 4i1nA-4nmnA:
undetectable		 4i1nA-4nmnA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 LEU A  52
MET A  21
ASP A  84
 None
 0.75A 4j7xB-4nmnA:
2.4		 4j7xB-4nmnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		4 / 8 SER A 275
SER A 252
ILE A 264
GLU A 267
 None
 1.25A 4ms4A-4nmnA:
3.7		 4ms4A-4nmnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 ASP A 190
LEU A 189
PHE A 186
 None
 0.62A 4pthA-4nmnA:
undetectable		 4pthA-4nmnA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		5 / 12 LEU A  18
LEU A  47
LEU A  52
ASN A  54
ILE A  68
 None
 1.18A 4x1yB-4nmnA:
undetectable		 4x1yB-4nmnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 1.04A 5ewzB-4nmnA:
2.9		 5ewzB-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		4 / 8 LEU A 272
LEU A 247
THR A 433
TYR A 432
 None
None
ADP  A1001 (-4.7A)
None
 0.95A 5hbsA-4nmnA:
0.9		 5hbsA-4nmnA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 1.00A 5m35B-4nmnA:
undetectable		 5m35B-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.96A 5m36A-4nmnA:
2.6		 5m36A-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.99A 6fn9A-4nmnA:
undetectable		 6fn9A-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 1.01A 6fnaB-4nmnA:
2.2		 6fnaB-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4nmn REPLICATIVE DNA
HELICASE
(Aquifex
aeolicus) 		3 / 3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.97A 6fnbA-4nmnA:
undetectable		 6fnbA-4nmnA:
19.35