SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 GLY A  85
VAL A  17
LEU A  16
MET A 197
ALA A 101
 None
 1.22A 1e3vA-4nmwA:
undetectable		 1e3vA-4nmwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 11 GLY A  21
SER A  82
LEU A 183
LEU A 161
HIS A 235
 CL  A 301 ( 4.0A)
CL  A 301 (-2.8A)
None
None
None
 1.10A 1mx1A-4nmwA:
11.5		 1mx1A-4nmwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 11 LEU A  79
LEU A 252
LEU A 256
LEU A  36
LEU A 249
 None
 1.31A 1mx1B-4nmwA:
11.5		 1mx1B-4nmwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 10 ASP A  46
TRP A  29
GLY A  85
GLY A  84
SER A  82
 None
None
None
None
CL  A 301 (-2.8A)
 1.17A 1w76B-4nmwA:
10.8		 1w76B-4nmwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 183
GLY A  23
GLY A  21
LEU A  19
GLY A  80
 None
None
CL  A 301 ( 4.0A)
None
None
 1.16A 1y4lA-4nmwA:
undetectable		 1y4lA-4nmwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 8 SER A 240
ALA A 244
PHE A 245
LEU A  79
 None
 0.88A 2bxmA-4nmwA:
undetectable		 2bxmA-4nmwA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 ALA A 145
GLN A 131
PHE A 143
ILE A 120
LEU A 125
 None
 1.22A 3ia4C-4nmwA:
undetectable		 3ia4C-4nmwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 11 GLY A  80
LEU A  83
SER A 107
LEU A  47
LEU A  19
 None
CL  A 301 (-4.4A)
None
None
None
 1.36A 3ndvA-4nmwA:
undetectable
3ndvB-4nmwA:
undetectable		 3ndvA-4nmwA:
21.99
3ndvB-4nmwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 5 ARG A 189
LEU A 218
PRO A 211
ASP A 187
 None
 1.10A 3ufnA-4nmwA:
undetectable
3ufnB-4nmwA:
undetectable		 3ufnA-4nmwA:
15.95
3ufnB-4nmwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 5 ALA A 167
ASN A  25
ARG A  52
PRO A 169
 None
 1.30A 3vxiA-4nmwA:
undetectable		 3vxiA-4nmwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 238
PHE A 245
ALA A 106
LEU A  79
 None
 1.05A 4ejgA-4nmwA:
undetectable		 4ejgA-4nmwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 ARG A  33
HIS A  30
TYR A   9
 None
 1.24A 4fu8A-4nmwA:
undetectable		 4fu8A-4nmwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 ARG A  33
HIS A  30
TYR A   9
 None
 1.35A 4fu9A-4nmwA:
undetectable		 4fu9A-4nmwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 8 HIS A 235
TRP A  22
LEU A  24
LEU A 144
 None
 1.09A 4jtrA-4nmwA:
undetectable		 4jtrA-4nmwA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 7 LEU A 202
THR A 226
THR A 251
LEU A 252
 None
 0.82A 4z91F-4nmwA:
undetectable
4z91G-4nmwA:
undetectable
4z91H-4nmwA:
undetectable
4z91I-4nmwA:
undetectable
4z91J-4nmwA:
undetectable		 4z91F-4nmwA:
21.45
4z91G-4nmwA:
21.45
4z91H-4nmwA:
21.45
4z91I-4nmwA:
21.45
4z91J-4nmwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 126
LEU A  83
GLY A  49
LEU A 176
PHE A 143
 None
CL  A 301 (-4.4A)
None
None
None
 1.28A 4ze1A-4nmwA:
undetectable		 4ze1A-4nmwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 208
GLY A 119
ARG A 189
GLY A 204
LEU A 218
 None
 1.01A 5gwxA-4nmwA:
undetectable		 5gwxA-4nmwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.79A 5jsdA-4nmwA:
undetectable		 5jsdA-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.80A 5jsdB-4nmwA:
undetectable		 5jsdB-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.80A 5jsdC-4nmwA:
undetectable		 5jsdC-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.80A 5jseA-4nmwA:
undetectable		 5jseA-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.80A 5jseB-4nmwA:
undetectable		 5jseB-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		3 / 3 THR A 104
SER A 107
TYR A 203
 None
 0.81A 5jseC-4nmwA:
undetectable		 5jseC-4nmwA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 GLY A  21
GLY A 119
VAL A 210
ILE A 120
GLY A 179
 CL  A 301 ( 4.0A)
None
None
None
None
 0.94A 5koxA-4nmwA:
undetectable		 5koxA-4nmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 None
 0.76A 5uc1A-4nmwA:
undetectable		 5uc1A-4nmwA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 None
 0.78A 5uc1B-4nmwA:
undetectable		 5uc1B-4nmwA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		4 / 5 PRO A 237
VAL A 105
GLY A  23
VAL A  28
 None
 0.96A 6ak3B-4nmwA:
undetectable		 6ak3B-4nmwA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 12 HIS A  20
VAL A  87
LEU A 132
PHE A 136
GLY A  51
 None
 1.27A 6brdA-4nmwA:
undetectable		 6brdA-4nmwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE
(Salmonella
enterica) 		5 / 9 PRO A 198
VAL A 103
SER A 254
LEU A 256
ILE A  77
 None
 1.24A 6fdyU-4nmwA:
undetectable		 6fdyU-4nmwA:
24.27