SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nmy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 7 GLN A 249
THR A  19
SER A 229
TYR A 219
 None
 1.40A 1eiiA-4nmyA:
undetectable		 1eiiA-4nmyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 12 GLU A 228
GLY A  20
TYR A  29
GLY A 218
ALA A 222
 None
 1.25A 1httC-4nmyA:
undetectable		 1httC-4nmyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 4 GLY A 112
VAL A 140
TRP A 114
GLY A 115
 None
None
VIB  A 401 (-3.7A)
None
 1.11A 1ng8A-4nmyA:
undetectable		 1ng8A-4nmyA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 4 GLY A 112
VAL A 140
TRP A 114
GLY A 115
 None
None
VIB  A 401 (-3.7A)
None
 1.10A 1ng8B-4nmyA:
undetectable		 1ng8B-4nmyA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 6 LEU A  10
LEU A  21
PRO A 192
VAL A  84
 None
 1.08A 2dqyC-4nmyA:
undetectable		 2dqyC-4nmyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		3 / 3 VAL A 122
GLU A  64
GLU A 119
 None
VIB  A 401 (-2.9A)
None
 0.80A 2nv4A-4nmyA:
undetectable		 2nv4A-4nmyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 11 LEU A  25
ILE A  39
PHE A 211
PHE A  22
LEU A  10
 None
 1.28A 2q6hA-4nmyA:
undetectable		 2q6hA-4nmyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		3 / 3 VAL A  84
ASN A  15
TRP A  12
 None
VIB  A 401 (-3.3A)
VIB  A 401 (-3.6A)
 1.10A 2y00B-4nmyA:
undetectable		 2y00B-4nmyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 TYR A 189
PHE A 277
TYR A 274
ALA A 125
 None
 0.91A 3l4dA-4nmyA:
undetectable		 3l4dA-4nmyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 10 VAL A 180
LEU A 187
TYR A 274
PHE A 123
GLU A  64
 None
None
None
None
VIB  A 401 (-2.9A)
 1.37A 3qeoA-4nmyA:
0.0		 3qeoA-4nmyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 ASN A  17
GLU A 161
TYR A 251
LEU A 252
 None
 0.97A 3rqwC-4nmyA:
undetectable
3rqwD-4nmyA:
undetectable		 3rqwC-4nmyA:
19.94
3rqwD-4nmyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 ASN A  17
GLU A 161
TYR A 251
LEU A 252
 None
 0.97A 3rqwI-4nmyA:
undetectable
3rqwJ-4nmyA:
undetectable		 3rqwI-4nmyA:
19.94
3rqwJ-4nmyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 GLU A 161
TYR A 251
LEU A 252
ASN A  17
 None
 0.99A 3rqwF-4nmyA:
undetectable
3rqwJ-4nmyA:
undetectable		 3rqwF-4nmyA:
19.94
3rqwJ-4nmyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 12 TYR A 219
TRP A 263
LEU A  21
ALA A  82
GLY A  59
 None
 1.21A 4hfpB-4nmyA:
undetectable		 4hfpB-4nmyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 TYR A  30
THR A 215
THR A   7
LEU A  21
 None
 0.96A 4l4aA-4nmyA:
undetectable		 4l4aA-4nmyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		5 / 12 SER A 196
VAL A  40
ALA A  82
PHE A 211
LEU A  25
 None
 1.32A 4nc3A-4nmyA:
undetectable		 4nc3A-4nmyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		3 / 3 ASP A  26
LEU A  25
PHE A  22
 None
 0.46A 4pthA-4nmyA:
undetectable		 4pthA-4nmyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 6 VAL A  84
MET A   8
ILE A  60
ASP A  11
 None
 0.89A 5iwuA-4nmyA:
undetectable		 5iwuA-4nmyA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 4 GLN A  63
THR A 191
LEU A 183
LEU A 187
 None
VIB  A 401 (-3.0A)
None
None
 1.31A 5m5kB-4nmyA:
undetectable		 5m5kB-4nmyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 TRP A 114
GLN A  65
TRP A 158
VAL A 122
 VIB  A 401 (-3.7A)
None
VIB  A 401 (-4.0A)
None
 1.06A 5vlmA-4nmyA:
undetectable		 5vlmA-4nmyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Clostridioides
difficile) 		4 / 8 TRP A 114
GLN A  65
TRP A 158
VAL A 122
 VIB  A 401 (-3.7A)
None
VIB  A 401 (-4.0A)
None
 0.97A 5vlmF-4nmyA:
undetectable		 5vlmF-4nmyA:
19.61