SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		4 / 6 LEU A 168
PHE A 153
TYR A 136
VAL A 197
 None
 1.23A 1ibgH-4nn0A:
undetectable		 1ibgH-4nn0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A 229
ALA A 108
SER A 107
GLY A 194
HIS A 156
 None
 1.14A 1nbiC-4nn0A:
undetectable		 1nbiC-4nn0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A 229
ALA A 108
SER A 107
GLY A 194
HIS A 156
 None
 1.12A 1nbiD-4nn0A:
undetectable		 1nbiD-4nn0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 11 VAL A 159
PHE A 125
PHE A 227
GLY A 193
GLY A 194
 None
 1.35A 3owxA-4nn0A:
undetectable
3owxB-4nn0A:
undetectable		 3owxA-4nn0A:
22.08
3owxB-4nn0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 9 TYR A 136
VAL A 155
ALA A 154
GLY A 141
PHE A 125
 None
 1.19A 4mmeB-4nn0A:
undetectable		 4mmeB-4nn0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 12 MET A 196
GLY A 229
TYR A 152
ALA A 108
TYR A 136
 None
 1.31A 4ymgB-4nn0A:
undetectable		 4ymgB-4nn0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU A 123
TRP A 206
HIS A 156
GLY A 229
GLY A 141
 None
 1.15A 5d4uA-4nn0A:
undetectable		 5d4uA-4nn0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4nn0 COMPLEMENT C1Q TUMOR
NECROSIS
FACTOR-RELATED
PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 153
GLY A 229
VAL A 128
GLY A 194
PHE A 166
 None
 1.20A 6c2mB-4nn0A:
undetectable		 6c2mB-4nn0A:
17.45