SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.55A 1fbyA-4nn1A:
undetectable		 1fbyA-4nn1A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.54A 1fbyB-4nn1A:
undetectable		 1fbyB-4nn1A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.52A 1fm6A-4nn1A:
undetectable		 1fm6A-4nn1A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.54A 1xdkE-4nn1A:
undetectable		 1xdkE-4nn1A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.54A 1xiuA-4nn1A:
undetectable		 1xiuA-4nn1A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.55A 1xiuB-4nn1A:
undetectable		 1xiuB-4nn1A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.53A 2aclC-4nn1A:
undetectable		 2aclC-4nn1A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.58A 2aclE-4nn1A:
undetectable		 2aclE-4nn1A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.64A 2aclG-4nn1A:
undetectable		 2aclG-4nn1A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 8 SER A 101
PHE A  20
ALA A  16
ARG A  13
 None
 1.15A 2bxkA-4nn1A:
2.6		 2bxkA-4nn1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 137
SER A 136
TYR A 197
 None
 0.86A 2q2hA-4nn1A:
undetectable
2q2hB-4nn1A:
undetectable		 2q2hA-4nn1A:
20.52
2q2hB-4nn1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.56A 3e00A-4nn1A:
undetectable		 3e00A-4nn1A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.49A 3falA-4nn1A:
undetectable		 3falA-4nn1A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.50A 3falC-4nn1A:
undetectable		 3falC-4nn1A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 11 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.59A 3fc6A-4nn1A:
undetectable		 3fc6A-4nn1A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.48A 3oapA-4nn1A:
undetectable		 3oapA-4nn1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.51A 3uvvB-4nn1A:
undetectable		 3uvvB-4nn1A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.46A 4k6iA-4nn1A:
undetectable		 4k6iA-4nn1A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.64A 4nqaH-4nn1A:
undetectable		 4nqaH-4nn1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  43
LEU A  42
LEU A  53
GLY A  37
ALA A  36
 None
 1.04A 4rs0A-4nn1A:
3.3		 4rs0A-4nn1A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 GLU A  89
ARG A 168
ALA A 169
LEU A 171
 None
 1.15A 5phhA-4nn1A:
undetectable		 5phhA-4nn1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.66A 5uanA-4nn1A:
undetectable		 5uanA-4nn1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.58A 5z12C-4nn1A:
undetectable		 5z12C-4nn1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.49A 6a5yD-4nn1A:
undetectable		 6a5yD-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.49A 6a5zD-4nn1A:
undetectable		 6a5zD-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.48A 6a5zL-4nn1A:
undetectable		 6a5zL-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nn1 TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.41A 6a60D-4nn1A:
undetectable		 6a60D-4nn1A:
17.87