SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 PHE A 348
PHE A 316
ALA A  13
HIS A 224
HIS A 222
 OAA  A 602 (-4.8A)
None
OAA  A 602 ( 4.5A)
MG  A 601 ( 3.3A)
MG  A 601 ( 3.4A)
 1.45A 1a4lB-4nnbA:
9.8		 1a4lB-4nnbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 TRP A 494
ARG A 195
THR A 493
 None
 0.96A 1df7A-4nnbA:
undetectable		 1df7A-4nnbA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 456
LEU A 455
ILE A 425
GLY A 462
LEU A 465
 None
 1.16A 1g50B-4nnbA:
undetectable		 1g50B-4nnbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 11 LEU A 456
LEU A 455
ILE A 425
GLY A 462
LEU A 465
 None
 1.16A 1g50C-4nnbA:
undetectable		 1g50C-4nnbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 11 VAL A 314
GLY A 321
HIS A 224
PHE A 348
GLU A 473
 None
None
MG  A 601 ( 3.3A)
OAA  A 602 (-4.8A)
MG  A 601 ( 2.6A)
 1.36A 1iolA-4nnbA:
2.4		 1iolA-4nnbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 GLU A 473
HIS A 222
HIS A 224
 MG  A 601 ( 2.6A)
MG  A 601 ( 3.4A)
MG  A 601 ( 3.3A)
 0.68A 1oe2A-4nnbA:
undetectable		 1oe2A-4nnbA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 10 ALA A 420
ILE A 405
VAL A 459
ALA A 460
LEU A 375
 None
 1.17A 1xp0A-4nnbA:
undetectable		 1xp0A-4nnbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 10 MET A 176
LEU A 172
ILE A 129
ARG A 128
GLY A  59
 None
 1.40A 2qd4B-4nnbA:
undetectable		 2qd4B-4nnbA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 5 GLU A 235
PRO A 237
ILE A 236
GLY A 240
 None
 0.87A 2qeuA-4nnbA:
1.0
2qeuC-4nnbA:
1.1		 2qeuA-4nnbA:
14.84
2qeuC-4nnbA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 11 LEU A 455
ILE A 397
ALA A 377
GLU A 433
LEU A 465
 None
 1.27A 2v0mA-4nnbA:
undetectable		 2v0mA-4nnbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 9 LEU A 455
ILE A 397
ALA A 377
GLY A 464
LEU A 465
 None
 1.02A 2v0mB-4nnbA:
undetectable		 2v0mB-4nnbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 11 LEU A 455
ILE A 397
ALA A 377
GLU A 433
LEU A 465
 None
 1.25A 2v0mD-4nnbA:
undetectable		 2v0mD-4nnbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 8 TYR A 322
SER A 310
HIS A 222
SER A 308
 OAA  A 602 (-4.3A)
OAA  A 602 ( 4.7A)
MG  A 601 ( 3.4A)
OAA  A 602 (-2.5A)
 1.21A 2vmyA-4nnbA:
undetectable
2vmyB-4nnbA:
undetectable		 2vmyA-4nnbA:
22.48
2vmyB-4nnbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 4 ILE A 468
GLN A 496
ILE A 511
LEU A 472
 None
 1.31A 3dzyD-4nnbA:
undetectable		 3dzyD-4nnbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 10 MET A 176
LEU A 172
ILE A 129
ARG A 128
GLY A  59
 None
 1.31A 3hcpB-4nnbA:
1.2		 3hcpB-4nnbA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 10 SER A 310
LEU A 223
SER A 275
ILE A  11
ASP A 474
 OAA  A 602 ( 4.7A)
None
OAA  A 602 (-2.8A)
None
None
 1.48A 3ko0O-4nnbA:
undetectable
3ko0P-4nnbA:
undetectable
3ko0Q-4nnbA:
undetectable
3ko0R-4nnbA:
undetectable		 3ko0O-4nnbA:
10.93
3ko0P-4nnbA:
10.93
3ko0Q-4nnbA:
10.93
3ko0R-4nnbA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 6 TYR A 198
VAL A 221
ILE A  11
ARG A 215
 None
 1.06A 3pyyA-4nnbA:
undetectable		 3pyyA-4nnbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 VAL A 306
ILE A 271
ASN A 273
GLU A 473
VAL A 517
 None
None
None
MG  A 601 ( 2.6A)
None
 1.02A 4a97B-4nnbA:
undetectable
4a97C-4nnbA:
undetectable		 4a97B-4nnbA:
21.28
4a97C-4nnbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 5 LEU A 408
ASP A 415
ARG A 418
ARG A 419
 None
 1.44A 4cpzA-4nnbA:
undetectable		 4cpzA-4nnbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 4 PRO A  27
LEU A  31
ILE A  43
ARG A  39
 None
 1.42A 4f4dA-4nnbA:
undetectable		 4f4dA-4nnbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 456
LEU A 455
ILE A 425
GLY A 462
LEU A 465
 None
 1.28A 4j26A-4nnbA:
undetectable		 4j26A-4nnbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 121
LEU A 125
ILE A 129
SER A 169
LEU A 172
 None
 0.81A 4lmnA-4nnbA:
undetectable		 4lmnA-4nnbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 ILE A 352
ASP A 466
ILE A 444
ARG A 436
LEU A 364
 None
 0.98A 4m2xA-4nnbA:
undetectable		 4m2xA-4nnbA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 9 LEU A 435
ASN A 355
VAL A 347
VAL A 345
LEU A 309
 None
 1.21A 4qd3A-4nnbA:
undetectable		 4qd3A-4nnbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 ARG A 488
THR A 493
TRP A 494
 None
 1.22A 4ug5A-4nnbA:
undetectable		 4ug5A-4nnbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 GLY A  59
ALA A 185
ILE A 162
GLU A 166
LEU A  61
 None
 1.12A 4uw0A-4nnbA:
undetectable		 4uw0A-4nnbA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 6 GLU A 473
GLY A  51
ASP A  50
GLY A 192
 MG  A 601 ( 2.6A)
None
None
None
 0.92A 5cdnR-4nnbA:
undetectable
5cdnS-4nnbA:
undetectable		 5cdnR-4nnbA:
23.65
5cdnS-4nnbA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 6 GLU A 473
GLY A  51
ASP A  50
GLY A 192
 MG  A 601 ( 2.6A)
None
None
None
 0.93A 5cdnT-4nnbA:
undetectable
5cdnU-4nnbA:
undetectable		 5cdnT-4nnbA:
23.65
5cdnU-4nnbA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 8 VAL A 221
ALA A   8
GLY A 471
GLY A 492
 None
 0.91A 5e26C-4nnbA:
2.2
5e26D-4nnbA:
undetectable		 5e26C-4nnbA:
21.04
5e26D-4nnbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 TYR A 136
PHE A  25
GLY A 192
GLY A 187
VAL A  55
 None
 0.96A 5i71A-4nnbA:
undetectable		 5i71A-4nnbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 TYR A 136
PHE A  25
GLY A 192
GLY A 187
VAL A  55
 None
 0.94A 5i73A-4nnbA:
undetectable		 5i73A-4nnbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 10 ILE A 446
LEU A 456
ILE A 405
LEU A 409
LEU A 463
 None
 1.20A 5ienB-4nnbA:
undetectable		 5ienB-4nnbA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 435
ILE A 444
LEU A 463
GLY A 464
ILE A 446
 None
 1.07A 5j7wC-4nnbA:
undetectable		 5j7wC-4nnbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 5 SER A 498
VAL A 497
GLY A 217
ALA A 216
 None
 0.84A 5k50A-4nnbA:
2.6		 5k50A-4nnbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 7 LEU A 274
ILE A 211
THR A 210
MET A 214
 None
 1.44A 5ljcA-4nnbA:
undetectable		 5ljcA-4nnbA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 ILE A 425
LEU A 463
GLY A 378
ALA A 377
LEU A 375
 None
 1.13A 5zwrA-4nnbA:
undetectable		 5zwrA-4nnbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		4 / 7 ILE A 201
PRO A  15
ILE A 206
THR A 210
 None
 0.99A 6cduF-4nnbA:
undetectable
6cduG-4nnbA:
undetectable		 6cduF-4nnbA:
20.40
6cduG-4nnbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 LEU A 512
GLN A 516
LYS A 443
 None
 0.97A 6exiB-4nnbA:
undetectable		 6exiB-4nnbA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 LEU A 512
GLN A 516
LYS A 443
 None
 0.94A 6exiA-4nnbA:
undetectable		 6exiA-4nnbA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 LEU A 423
LEU A 408
ARG A 419
 None
 0.55A 6fgcA-4nnbA:
undetectable		 6fgcA-4nnbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		3 / 3 LEU A 423
LEU A 408
ARG A 419
 None
 0.58A 6fgdA-4nnbA:
undetectable		 6fgdA-4nnbA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 435
ILE A 444
LEU A 463
GLY A 464
ILE A 446
 None
 1.14A 6qyaB-4nnbA:
undetectable		 6qyaB-4nnbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A
(Burkholderia
glumae) 		5 / 12 LEU A 435
ILE A 444
LEU A 463
GLY A 464
ILE A 446
 None
 1.12A 6qyaD-4nnbA:
undetectable		 6qyaD-4nnbA:
22.56