SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 4 LYS A 298
LEU A 184
LEU A 145
SER A 144
 None
 1.35A 1tt6A-4nnpA:
undetectable		 1tt6A-4nnpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		3 / 3 GLY A  51
ASP A  52
ASN A  48
 None
 0.59A 1vq1A-4nnpA:
undetectable		 1vq1A-4nnpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 4 LEU A  42
ASP A  55
VAL A  84
THR A 158
 None
 1.31A 3cyxB-4nnpA:
undetectable		 3cyxB-4nnpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		5 / 12 THR A 158
VAL A  84
ILE A  85
ASN A  88
VAL A  36
 None
 1.00A 3kpdC-4nnpA:
undetectable		 3kpdC-4nnpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 6 TYR A 293
ASN A 185
LEU A 145
ASP A 146
 None
 1.44A 3lslG-4nnpA:
undetectable		 3lslG-4nnpA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		3 / 3 THR A  38
ASN A  39
GLU A  93
 None
 0.75A 3v4tA-4nnpA:
undetectable
3v4tC-4nnpA:
undetectable		 3v4tA-4nnpA:
22.97
3v4tC-4nnpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		5 / 12 TYR A 222
ILE A 218
GLU A 225
HIS A 251
VAL A 304
 None
 1.48A 4a97A-4nnpA:
1.9
4a97B-4nnpA:
1.9		 4a97A-4nnpA:
20.13
4a97B-4nnpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 6 TYR A 151
GLU A  93
THR A  38
LEU A  42
 None
 1.48A 4qztA-4nnpA:
undetectable		 4qztA-4nnpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		5 / 10 PHE A 209
ALA A 208
VAL A 278
LEU A 252
LEU A 253
 None
 1.26A 4zmeB-4nnpA:
undetectable		 4zmeB-4nnpA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 6 PHE A  99
ASN A  88
LEU A  92
GLY A  95
 None
 1.06A 5o4yA-4nnpA:
undetectable		 5o4yA-4nnpA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4nnp LIPOPROTEIN
(Staphylococcus
aureus) 		4 / 7 LEU A  92
VAL A 254
GLU A 206
SER A 257
 None
 1.26A 5umwA-4nnpA:
undetectable
5umwF-4nnpA:
undetectable		 5umwA-4nnpA:
13.06
5umwF-4nnpA:
13.06