SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nnq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 GLY A 119
LEU A  33
LEU A  38
LEU A  59
ALA A 126
 None
 1.08A 1gseB-4nnqA:
undetectable		 1gseB-4nnqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 11 GLY A 119
ALA A 123
ALA A 124
LEU A 155
VAL A 129
 None
 1.08A 1ukbA-4nnqA:
undetectable		 1ukbA-4nnqA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		4 / 5 ASN A  31
ASP A  71
THR A 253
SER A  26
 None
 1.02A 3p2kC-4nnqA:
undetectable		 3p2kC-4nnqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 GLY A 121
ALA A 124
THR A 159
ALA A 109
VAL A 129
 None
 1.36A 4df3A-4nnqA:
undetectable		 4df3A-4nnqA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.75A 4fp9A-4nnqA:
undetectable		 4fp9A-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.75A 4fp9C-4nnqA:
undetectable		 4fp9C-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.74A 4fp9D-4nnqA:
undetectable		 4fp9D-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.74A 4fp9F-4nnqA:
undetectable		 4fp9F-4nnqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 CYH A  67
GLY A  64
GLY A  63
GLY A 118
LEU A  33
 None
 0.77A 4fzvA-4nnqA:
undetectable		 4fzvA-4nnqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		4 / 7 VAL A 154
MET A  97
LEU A  94
ASP A 229
 None
 1.24A 4hxyB-4nnqA:
undetectable		 4hxyB-4nnqA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 11 ALA A 125
LEU A 122
LEU A  33
LEU A  38
LEU A  41
 None
 0.98A 4wg0E-4nnqA:
undetectable
4wg0F-4nnqA:
undetectable
4wg0G-4nnqA:
undetectable		 4wg0E-4nnqA:
3.86
4wg0F-4nnqA:
3.86
4wg0G-4nnqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		6 / 9 ALA A  44
LEU A  57
ALA A  22
LEU A  59
LEU A 122
LEU A  96
 None
 1.03A 4z91F-4nnqA:
undetectable
4z91G-4nnqA:
undetectable
4z91H-4nnqA:
undetectable
4z91I-4nnqA:
undetectable
4z91J-4nnqA:
undetectable		 4z91F-4nnqA:
18.35
4z91G-4nnqA:
18.35
4z91H-4nnqA:
18.35
4z91I-4nnqA:
18.35
4z91J-4nnqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		6 / 9 LEU A  45
ALA A  44
LEU A  57
ALA A  22
LEU A  59
LEU A  96
 None
 1.23A 4z91F-4nnqA:
undetectable
4z91G-4nnqA:
undetectable
4z91H-4nnqA:
undetectable
4z91I-4nnqA:
undetectable
4z91J-4nnqA:
undetectable		 4z91F-4nnqA:
18.35
4z91G-4nnqA:
18.35
4z91H-4nnqA:
18.35
4z91I-4nnqA:
18.35
4z91J-4nnqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		6 / 9 LEU A  57
ALA A  22
LEU A  59
LEU A  96
LEU A  45
ALA A  44
 None
 1.23A 4z91F-4nnqA:
undetectable
4z91G-4nnqA:
undetectable
4z91H-4nnqA:
undetectable
4z91I-4nnqA:
undetectable
4z91J-4nnqA:
undetectable		 4z91F-4nnqA:
18.35
4z91G-4nnqA:
18.35
4z91H-4nnqA:
18.35
4z91I-4nnqA:
18.35
4z91J-4nnqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		6 / 9 LEU A  57
ALA A  22
LEU A  59
LEU A 122
LEU A  96
ALA A  44
 None
 1.04A 4z91F-4nnqA:
undetectable
4z91G-4nnqA:
undetectable
4z91H-4nnqA:
undetectable
4z91I-4nnqA:
undetectable
4z91J-4nnqA:
undetectable		 4z91F-4nnqA:
18.35
4z91G-4nnqA:
18.35
4z91H-4nnqA:
18.35
4z91I-4nnqA:
18.35
4z91J-4nnqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 ALA A 195
PHE A  66
ALA A  37
ALA A  40
LEU A  57
 None
 1.22A 5tl8A-4nnqA:
undetectable		 5tl8A-4nnqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A  59
PHE A 100
ALA A  43
ALA A  36
GLY A  89
 None
 1.09A 5veuA-4nnqA:
undetectable		 5veuA-4nnqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4nnq PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
atroolivaceus) 		4 / 5 LEU A 155
VAL A 151
GLU A 141
LEU A 139
 None
 1.07A 5xooB-4nnqA:
undetectable		 5xooB-4nnqA:
13.14