SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 393
ASP A 390
GLU A 392
LEU A 391
ILE A 402
 None
 1.24A 1errA-4nnzA:
undetectable		 1errA-4nnzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 192
ALA A 207
VAL A 194
LEU A 100
GLN A  93
 None
 1.32A 1rlbE-4nnzA:
undetectable		 1rlbE-4nnzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 272
TYR A 300
ARG A 269
ASP A 276
ALA A 273
 None
 1.14A 2br4E-4nnzA:
undetectable		 2br4E-4nnzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  37
GLY A  48
GLU A  42
HIS A  51
GLY A  38
 None
 1.37A 2fn1A-4nnzA:
undetectable		 2fn1A-4nnzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A  37
GLY A  48
GLU A  42
HIS A  51
GLY A  38
 None
 1.42A 2fn1B-4nnzA:
undetectable		 2fn1B-4nnzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
GLU A 363
 None
 1.15A 2nsiA-4nnzA:
undetectable
2nsiB-4nnzA:
undetectable		 2nsiA-4nnzA:
23.35
2nsiB-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 0.99A 2nsiA-4nnzA:
undetectable
2nsiB-4nnzA:
undetectable		 2nsiA-4nnzA:
23.35
2nsiB-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.03A 2nsiA-4nnzA:
undetectable
2nsiB-4nnzA:
undetectable		 2nsiA-4nnzA:
23.35
2nsiB-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.02A 2nsiC-4nnzA:
undetectable
2nsiD-4nnzA:
undetectable		 2nsiC-4nnzA:
23.35
2nsiD-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.01A 2nsiC-4nnzA:
undetectable
2nsiD-4nnzA:
undetectable		 2nsiC-4nnzA:
23.35
2nsiD-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 271
ALA A 406
GLN A 403
ILE A 349
LEU A 339
 None
 1.05A 3dzuA-4nnzA:
undetectable		 3dzuA-4nnzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
GLU A 363
 None
 1.16A 3e7gA-4nnzA:
undetectable
3e7gB-4nnzA:
undetectable		 3e7gA-4nnzA:
23.28
3e7gB-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.04A 3e7gA-4nnzA:
undetectable
3e7gB-4nnzA:
undetectable		 3e7gA-4nnzA:
23.28
3e7gB-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 363
MET A 360
ARG A 269
ILE A 387
 None
 1.17A 3e7gA-4nnzA:
undetectable
3e7gB-4nnzA:
undetectable		 3e7gA-4nnzA:
23.28
3e7gB-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.06A 3e7gA-4nnzA:
undetectable
3e7gB-4nnzA:
undetectable		 3e7gA-4nnzA:
23.28
3e7gB-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
GLU A 363
 None
 1.22A 3e7gC-4nnzA:
undetectable
3e7gD-4nnzA:
undetectable		 3e7gC-4nnzA:
23.28
3e7gD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.09A 3e7gC-4nnzA:
undetectable
3e7gD-4nnzA:
undetectable		 3e7gC-4nnzA:
23.28
3e7gD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.11A 3e7gC-4nnzA:
undetectable
3e7gD-4nnzA:
undetectable		 3e7gC-4nnzA:
23.28
3e7gD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.06A 3ej8A-4nnzA:
undetectable
3ej8B-4nnzA:
undetectable		 3ej8A-4nnzA:
23.28
3ej8B-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.13A 3ej8A-4nnzA:
undetectable
3ej8B-4nnzA:
undetectable		 3ej8A-4nnzA:
23.28
3ej8B-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.08A 3ej8C-4nnzA:
undetectable
3ej8D-4nnzA:
undetectable		 3ej8C-4nnzA:
23.28
3ej8D-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.12A 3ej8C-4nnzA:
undetectable
3ej8D-4nnzA:
undetectable		 3ej8C-4nnzA:
23.28
3ej8D-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 5 LYS A 224
SER A  39
LEU A 226
SER A 156
 PEG  A 501 (-3.1A)
None
None
None
 1.20A 3iluH-4nnzA:
undetectable		 3iluH-4nnzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 GLN A 376
ARG A 269
ASP A 302
PHE A 304
 None
 1.10A 3mjrD-4nnzA:
undetectable		 3mjrD-4nnzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 349
GLN A 403
ALA A 267
LEU A 270
 None
 0.87A 3ozwA-4nnzA:
undetectable		 3ozwA-4nnzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.13A 4cx7A-4nnzA:
undetectable
4cx7B-4nnzA:
undetectable		 4cx7A-4nnzA:
23.35
4cx7B-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.14A 4cx7A-4nnzA:
undetectable
4cx7B-4nnzA:
undetectable		 4cx7A-4nnzA:
23.35
4cx7B-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.05A 4cx7C-4nnzA:
0.0
4cx7D-4nnzA:
undetectable		 4cx7C-4nnzA:
23.35
4cx7D-4nnzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 269
PHE A 311
GLY A 277
THR A 299
 None
 0.93A 4k87A-4nnzA:
undetectable		 4k87A-4nnzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 304
MET A 360
ARG A 269
ILE A 387
 None
 1.22A 4nosA-4nnzA:
undetectable
4nosB-4nnzA:
undetectable		 4nosA-4nnzA:
23.28
4nosB-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 MET A 360
ARG A 269
ILE A 387
PHE A 304
 None
 1.07A 4nosC-4nnzA:
undetectable
4nosD-4nnzA:
undetectable		 4nosC-4nnzA:
23.28
4nosD-4nnzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  42
THR A  84
GLY A  38
THR A  89
 None
 0.95A 4qwpB-4nnzA:
undetectable		 4qwpB-4nnzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4nnz PROBABLE ZINC
PROTEASE
(Pseudomonas
aeruginosa) 		5 / 10 SER A 298
LEU A 339
LEU A 336
SER A 314
LEU A 313
 None
 1.19A 4yiaA-4nnzA:
undetectable		 4yiaA-4nnzA:
19.96