SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4noi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 ILE A  59
MET A  74
PHE A 141
ILE A 111
LEU A 116
 None
 1.27A 1rh3A-4noiA:
undetectable		 1rh3A-4noiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 ILE A  59
MET A  74
PHE A 141
ILE A 111
LEU A 116
 None
 1.12A 1rx3A-4noiA:
undetectable		 1rx3A-4noiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 LEU A 143
ILE A 111
MET A  74
PHE A 141
ILE A  59
 None
 1.37A 1xotA-4noiA:
undetectable		 1xotA-4noiA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		3 / 3 LEU A  43
PRO A  42
LEU A  46
 None
IOD  A 402 ( 4.2A)
None
 0.58A 2po7B-4noiA:
undetectable		 2po7B-4noiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		4 / 8 ILE A 111
PHE A 141
LEU A  88
LEU A  85
 None
 0.85A 2w98B-4noiA:
undetectable		 2w98B-4noiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 VAL A 121
LEU A 169
PHE A 141
GLY A 113
LEU A 130
 None
 1.06A 3j6pB-4noiA:
undetectable		 3j6pB-4noiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 ILE A  59
MET A  74
PHE A 141
ILE A 111
LEU A 116
 None
 1.10A 3ql0A-4noiA:
undetectable		 3ql0A-4noiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		3 / 3 GLN A 214
THR A 208
ASN A 210
 None
 0.89A 3v4tE-4noiA:
undetectable		 3v4tE-4noiA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		4 / 8 PHE A 103
PHE A 141
LEU A  88
LEU A  85
 None
 0.92A 4ejgB-4noiA:
undetectable		 4ejgB-4noiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 GLU A 211
THR A 203
THR A  51
VAL A 124
ASP A  21
 None
 1.50A 4njgB-4noiA:
undetectable		 4njgB-4noiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 ILE A  59
MET A  74
PHE A 141
ILE A 111
LEU A 116
 None
 1.17A 4rgcA-4noiA:
undetectable		 4rgcA-4noiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		4 / 6 LEU A  85
ILE A  59
ALA A  58
ALA A 171
 None
 0.65A 4zf8A-4noiA:
undetectable		 4zf8A-4noiA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Campylobacter
jejuni) 		5 / 12 VAL A 121
LEU A 169
PHE A 141
GLY A 113
LEU A 130
 None
 1.08A 5ogcB-4noiA:
undetectable		 5ogcB-4noiA:
20.51