SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4non'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 4 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.96A 1e7bA-4nonA:
undetectable		 1e7bA-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 4 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.97A 1e7bB-4nonA:
undetectable		 1e7bB-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 5 ARG A 197
ALA A 200
ALA A 179
GLU A 177
 ARG  A 197 ( 0.6A)
ALA  A 200 ( 0.0A)
ALA  A 179 ( 0.0A)
GLU  A 177 ( 0.6A)
 0.95A 1e7cA-4nonA:
undetectable		 1e7cA-4nonA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		5 / 12 ILE A 106
ALA A   5
ALA A  70
LEU A  97
ILE A  57
 ILE  A 106 ( 0.6A)
ALA  A   5 ( 0.0A)
ALA  A  70 ( 0.0A)
LEU  A  97 ( 0.6A)
ILE  A  57 ( 0.7A)
 1.02A 3gwsX-4nonA:
undetectable		 3gwsX-4nonA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 4 ILE A 201
ARG A 175
ILE A 180
THR A  99
 ILE  A 201 ( 0.7A)
ARG  A 175 ( 0.6A)
ILE  A 180 ( 0.6A)
THR  A  99 ( 0.8A)
 1.01A 3ia4C-4nonA:
2.1		 3ia4C-4nonA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		5 / 12 ILE A 251
LEU A  91
LEU A 130
LEU A 134
ILE A 110
 ILE  A 251 ( 0.6A)
LEU  A  91 ( 0.6A)
LEU  A 130 ( 0.6A)
LEU  A 134 ( 0.6A)
ILE  A 110 ( 0.7A)
 0.80A 3uvvA-4nonA:
undetectable		 3uvvA-4nonA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 7 PHE A 250
TYR A 172
ILE A 201
PRO A 170
 PHE  A 250 ( 1.3A)
TYR  A 172 ( 1.3A)
ILE  A 201 ( 0.7A)
PRO  A 170 ( 1.1A)
 0.98A 4g5jA-4nonA:
undetectable		 4g5jA-4nonA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		4 / 6 LEU A  95
ASN A  84
GLN A 100
LEU A 101
 LEU  A  95 ( 0.6A)
ASN  A  84 ( 0.6A)
GLN  A 100 ( 0.6A)
LEU  A 101 ( 0.6A)
 1.27A 4nc3A-4nonA:
undetectable		 4nc3A-4nonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		3 / 3 SER A 142
ALA A 140
VAL A 139
 SER  A 142 (-0.0A)
ALA  A 140 ( 0.0A)
VAL  A 139 ( 0.6A)
 0.50A 4o2bA-4nonA:
undetectable		 4o2bA-4nonA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B
(Streptococcus
thermophilus) 		5 / 12 ASN A   9
LEU A  97
ASN A  84
GLY A  13
ILE A 115
 ASN  A   9 ( 0.6A)
LEU  A  97 ( 0.6A)
ASN  A  84 ( 0.6A)
GLY  A  13 (-0.0A)
ILE  A 115 ( 0.4A)
 1.33A 6dwnA-4nonA:
undetectable		 6dwnA-4nonA:
15.29