SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 ALA A 218
VAL A 216
TRP A 205
 None
 0.97A 1c4dA-4novA:
undetectable
1c4dB-4novA:
undetectable		 1c4dA-4novA:
6.07
1c4dB-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 TRP A 205
ALA A 218
VAL A 216
 None
 0.94A 1c4dA-4novA:
undetectable
1c4dB-4novA:
undetectable		 1c4dA-4novA:
6.07
1c4dB-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 ALA A 218
VAL A 216
TRP A 205
 None
 0.89A 1c4dC-4novA:
undetectable
1c4dD-4novA:
undetectable		 1c4dC-4novA:
6.07
1c4dD-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 TRP A 205
ALA A 218
VAL A 216
 None
 0.86A 1c4dC-4novA:
undetectable
1c4dD-4novA:
undetectable		 1c4dC-4novA:
6.07
1c4dD-4novA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 TYR A  50
ASP A  24
VAL A 254
ASP A  41
ALA A  23
 None
TRS  A 402 (-2.9A)
None
None
None
 1.47A 1e3vA-4novA:
undetectable		 1e3vA-4novA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 7 PHE A 124
PRO A 120
ALA A  90
PHE A  97
 None
 1.17A 1lqtA-4novA:
undetectable		 1lqtA-4novA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 7 PHE A 124
PRO A 120
ALA A  90
PHE A  97
 None
 1.18A 1lquA-4novA:
undetectable		 1lquA-4novA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 ALA A 218
VAL A 216
TRP A 205
 None
 0.73A 1tkqB-4novA:
undetectable		 1tkqB-4novA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 11 TYR A 243
GLY A 192
THR A 198
ALA A 190
VAL A 246
 None
 1.45A 2cojA-4novA:
undetectable
2cojB-4novA:
undetectable		 2cojA-4novA:
21.85
2cojB-4novA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 PHE A 292
ALA A 219
PRO A 259
GLY A 203
GLY A 201
 None
None
None
CA  A 401 ( 4.7A)
None
 1.09A 2igtA-4novA:
undetectable		 2igtA-4novA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 PHE A 292
ALA A 219
PRO A 259
GLY A 203
GLY A 201
 None
None
None
CA  A 401 ( 4.7A)
None
 1.09A 2igtB-4novA:
undetectable		 2igtB-4novA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 9 VAL A 254
GLY A 275
SER A 281
LEU A  45
ASP A  41
 None
 0.93A 2j2pB-4novA:
undetectable
2j2pC-4novA:
undetectable		 2j2pB-4novA:
20.23
2j2pC-4novA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 PRO A  25
THR A  38
ILE A  20
PRO A  15
LEU A 277
 None
 1.38A 3a51B-4novA:
undetectable		 3a51B-4novA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 5 PRO A 302
VAL A 246
THR A 274
GLY A 253
 None
 0.81A 3elzB-4novA:
2.5		 3elzB-4novA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 ILE A  20
ASP A 141
ILE A 140
ARG A 285
HIS A 258
 None
TRS  A 402 (-3.0A)
None
TRS  A 402 (-2.9A)
CA  A 401 (-3.7A)
 1.41A 3phaB-4novA:
undetectable		 3phaB-4novA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 12 ILE A  20
ASP A 141
ILE A 140
ARG A 285
HIS A 258
 None
TRS  A 402 (-3.0A)
None
TRS  A 402 (-2.9A)
CA  A 401 (-3.7A)
 1.41A 3phaD-4novA:
undetectable		 3phaD-4novA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 TYR A  35
ASP A  32
ASP A  62
 None
 0.44A 4a6eA-4novA:
undetectable		 4a6eA-4novA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 HIS A 258
GLU A 227
ASN A 158
 CA  A 401 (-3.7A)
None
None
 0.85A 4bupB-4novA:
undetectable		 4bupB-4novA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 CYH A 288
ASN A 257
LYS A 305
 None
 1.49A 4k50A-4novA:
undetectable		 4k50A-4novA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 6 THR A  38
THR A  22
HIS A  12
LEU A  36
 None
 1.13A 4pgfA-4novA:
undetectable		 4pgfA-4novA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 8 ASP A  24
HIS A 273
TRP A  86
ARG A  84
 TRS  A 402 (-2.9A)
None
TRS  A 402 (-3.6A)
None
 0.74A 5nekB-4novA:
undetectable		 5nekB-4novA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 8 ASP A  24
HIS A 273
TRP A  86
ARG A  84
 TRS  A 402 (-2.9A)
None
TRS  A 402 (-3.6A)
None
 0.76A 5nekD-4novA:
undetectable		 5nekD-4novA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 8 ASN A 257
ILE A 261
MET A 248
LEU A 229
 None
 1.08A 5u4sB-4novA:
undetectable		 5u4sB-4novA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 HIS A 258
GLU A 227
ASN A 158
 CA  A 401 (-3.7A)
None
None
 0.84A 5wbvA-4novA:
undetectable		 5wbvA-4novA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		3 / 3 HIS A 258
GLU A 227
ASN A 158
 CA  A 401 (-3.7A)
None
None
 0.83A 5wbvB-4novA:
undetectable		 5wbvB-4novA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 8 GLU A 227
HIS A 273
PHE A 271
HIS A  12
 None
 1.08A 5y2tB-4novA:
undetectable		 5y2tB-4novA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 5 HIS A 228
ALA A 190
SER A 199
GLY A 221
 None
 1.10A 5yodB-4novA:
undetectable		 5yodB-4novA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		5 / 9 GLY A 253
TYR A 272
GLU A 251
ASP A 276
GLY A 275
 None
 1.31A 5zniA-4novA:
undetectable		 5zniA-4novA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 5 GLY A 157
ASN A 138
ASP A 139
ARG A 162
 None
 1.37A 6dwdB-4novA:
undetectable
6dwdD-4novA:
undetectable		 6dwdB-4novA:
20.45
6dwdD-4novA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E
(Butyrivibrio
proteoclasticus) 		4 / 5 ARG A 162
GLY A 157
ASN A 138
ASP A 139
 None
 1.38A 6dwjB-4novA:
undetectable
6dwjD-4novA:
undetectable		 6dwjB-4novA:
20.45
6dwjD-4novA:
20.45