SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_B_DVAB8_0
(GRAMICIDIN D)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 5 VAL A 194
TRP A 206
VAL A 172
TRP A 183
 None
 1.30A 1al4A-4noxA:
undetectable
1al4B-4noxA:
undetectable		 1al4A-4noxA:
8.11
1al4B-4noxA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_B_DVAB8_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 5 VAL A 194
TRP A 206
VAL A 172
TRP A 183
 None
 1.27A 1alzA-4noxA:
undetectable
1alzB-4noxA:
undetectable		 1alzA-4noxA:
1.90
1alzB-4noxA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		3 / 4 VAL A 172
TRP A 183
TRP A 206
 None
 1.09A 1gmkA-4noxA:
undetectable
1gmkB-4noxA:
undetectable		 1gmkA-4noxA:
8.11
1gmkB-4noxA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 7 THR A 254
GLY A 220
HIS A 237
THR A 214
 None
 0.93A 1gtnF-4noxA:
undetectable
1gtnG-4noxA:
undetectable		 1gtnF-4noxA:
11.44
1gtnG-4noxA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 6 PRO A 190
GLU A 622
PHE A 182
ARG A 175
 None
 1.32A 1oniA-4noxA:
undetectable
1oniC-4noxA:
undetectable		 1oniA-4noxA:
11.11
1oniC-4noxA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 5 PHE A 182
ARG A 175
PRO A 190
GLU A 622
 None
 1.31A 1oniG-4noxA:
undetectable
1oniH-4noxA:
undetectable		 1oniG-4noxA:
11.11
1oniH-4noxA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		3 / 3 ARG A 234
VAL A 204
THR A 200
 None
 0.80A 3cyxA-4noxA:
undetectable		 3cyxA-4noxA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		5 / 10 LEU A 329
VAL A 351
GLY A 393
VAL A 392
ILE A 335
 None
 1.03A 3oxwB-4noxA:
undetectable		 3oxwB-4noxA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 5 GLU A 444
VAL A 427
LEU A 408
VAL A 411
 None
 0.99A 4lb0B-4noxA:
undetectable		 4lb0B-4noxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		6 / 11 LEU A 329
ALA A 327
VAL A 351
ILE A 397
VAL A 356
ILE A 335
 None
 1.28A 4qgiB-4noxA:
undetectable		 4qgiB-4noxA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		3 / 3 GLY A 370
GLN A 367
LYS A 451
 None
 0.90A 5imsB-4noxA:
undetectable		 5imsB-4noxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 8 ASN A 278
ALA A 294
SER A 292
HIS A 237
 None
 0.87A 5km8A-4noxA:
undetectable
5km8B-4noxA:
undetectable		 5km8A-4noxA:
11.38
5km8B-4noxA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		4 / 4 PHE A 468
LEU A 406
LEU A 425
VAL A 429
 None
 1.21A 5xxiA-4noxA:
undetectable		 5xxiA-4noxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		5 / 12 SER A 547
HIS A 610
LEU A 618
LEU A 549
TYR A 612
 None
 1.47A 5y2oA-4noxA:
undetectable		 5y2oA-4noxA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Chaetomium
thermophilum) 		5 / 12 GLY A 581
HIS A 603
VAL A 594
VAL A 585
ASP A 584
 None
 1.05A 6bxlB-4noxA:
undetectable		 6bxlB-4noxA:
20.37