SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4np4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 7 TYR A1977
GLU A1947
TRP A1948
PHE A1979
 None
 1.45A 1b2iA-4np4A:
undetectable		 1b2iA-4np4A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1888
PHE A1856
TYR A1865
THR A1879
 None
 1.26A 3lb3A-4np4A:
undetectable		 3lb3A-4np4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1888
PHE A1856
TYR A1865
THR A1879
 None
 1.29A 3lb3B-4np4A:
undetectable		 3lb3B-4np4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 4 LEU A2100
ALA A2097
PHE A2090
ASN A2061
 None
 1.45A 3vaqA-4np4A:
undetectable		 3vaqA-4np4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 4 LEU A2100
ALA A2097
PHE A2090
ASN A2061
 None
 1.46A 3vasA-4np4A:
undetectable		 3vasA-4np4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.40A 4w5qA-4np4A:
undetectable		 4w5qA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.39A 4w5rA-4np4A:
undetectable		 4w5rA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.40A 4w5tA-4np4A:
undetectable		 4w5tA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.42A 4z4cA-4np4A:
undetectable		 4z4cA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.45A 4z4fA-4np4A:
undetectable		 4z4fA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 5 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.42A 4z4hA-4np4A:
undetectable		 4z4hA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 ASP A1924
ALA A1922
LYS A1906
TYR A1942
 None
 1.46A 4z4iA-4np4A:
undetectable		 4z4iA-4np4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4np4 TOXIN B
(Clostridioides
difficile) 		4 / 6 TYR A1977
LEU A1969
GLY A1968
PHE A1979
 None
 1.03A 5nooC-4np4A:
undetectable		 5nooC-4np4A:
21.34