SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 5 GLY A 215
LEU A 216
THR A 217
ARG A 243
 None
 0.79A 1ekjF-4npaA:
undetectable
1ekjG-4npaA:
undetectable		 1ekjF-4npaA:
21.43
1ekjG-4npaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 8 VAL A  10
TYR A  39
SER A  43
VAL A  46
 None
 1.17A 1jtvA-4npaA:
2.0		 1jtvA-4npaA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 246
PHE A 351
GLY A 136
ILE A 137
LEU A 234
 None
 1.19A 1kglA-4npaA:
undetectable		 1kglA-4npaA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 327
ILE A 330
ILE A 255
VAL A 153
ALA A 251
 None
 1.07A 1uduB-4npaA:
undetectable		 1uduB-4npaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 8 THR A  30
GLN A  37
SER A  33
TYR A  39
 None
 1.18A 2xz5A-4npaA:
undetectable
2xz5C-4npaA:
undetectable		 2xz5A-4npaA:
20.79
2xz5C-4npaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 8 THR A  30
GLN A  37
SER A  33
TYR A  39
 None
 1.20A 2xz5C-4npaA:
undetectable
2xz5D-4npaA:
undetectable		 2xz5C-4npaA:
20.79
2xz5D-4npaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 10 PRO A  84
ILE A  68
PRO A  12
LEU A 102
TYR A  39
 None
 1.43A 2ze2A-4npaA:
undetectable		 2ze2A-4npaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 305
ALA A 313
ILE A 270
LEU A 309
LEU A 288
 None
 1.10A 3dzuA-4npaA:
undetectable		 3dzuA-4npaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 SER A 104
GLU A 233
ASP A 108
ILE A 137
ASN A 140
 None
 1.47A 3jayA-4npaA:
undetectable		 3jayA-4npaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 VAL A 248
ILE A 286
LEU A 288
ILE A 305
LEU A 309
 None
 1.31A 3w67D-4npaA:
undetectable		 3w67D-4npaA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 PHE A  66
ILE A 222
ASN A  41
TYR A  36
VAL A 105
 None
 1.45A 4a97A-4npaA:
1.7
4a97B-4npaA:
1.8		 4a97A-4npaA:
20.96
4a97B-4npaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 5 ILE A 357
ILE A 270
TYR A 269
GLU A 266
 None
 1.20A 4a99D-4npaA:
undetectable		 4a99D-4npaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 10 ILE A 256
LEU A 288
GLY A 157
GLU A 165
GLY A 260
 None
None
None
None
SO4  A 501 (-3.4A)
 1.22A 4bwlC-4npaA:
undetectable		 4bwlC-4npaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 10 ILE A 256
LEU A 288
GLY A 158
GLU A 165
GLY A 260
 None
None
SO4  A 501 (-3.6A)
None
SO4  A 501 (-3.4A)
 1.21A 4bwlC-4npaA:
undetectable		 4bwlC-4npaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 7 GLY A 259
ILE A 161
ASN A 162
GLU A 165
 SO4  A 501 ( 3.9A)
None
None
None
 1.06A 4g0vA-4npaA:
2.5		 4g0vA-4npaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 GLY A 202
LEU A 181
ALA A 328
ARG A 170
ILE A 255
 None
 1.09A 4krhA-4npaA:
undetectable		 4krhA-4npaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 GLY A 202
LEU A 181
ALA A 328
ARG A 170
ILE A 255
 None
 1.12A 4krhB-4npaA:
undetectable		 4krhB-4npaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 8 ILE A 321
GLU A 295
ILE A 256
LEU A 301
 None
 0.74A 4mj8A-4npaA:
undetectable		 4mj8A-4npaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 5 GLY A 173
ALA A 199
GLY A 194
PRO A 195
 None
 0.98A 4u9uB-4npaA:
2.6		 4u9uB-4npaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 183
GLY A 173
ALA A 199
TYR A 166
GLU A 193
 None
 1.21A 4xt8A-4npaA:
undetectable		 4xt8A-4npaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		5 / 12 GLY A 420
LEU A 268
ILE A 256
GLY A 260
LEU A 431
 None
None
None
SO4  A 501 (-3.4A)
None
 1.16A 4ze2A-4npaA:
0.4		 4ze2A-4npaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 7 PHE A 257
ILE A 255
GLY A 173
THR A 185
 None
 1.16A 4zxiA-4npaA:
2.4		 4zxiA-4npaA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		3 / 3 ASN A 323
ALA A 325
ARG A 329
 None
 0.49A 5cvtB-4npaA:
2.7		 5cvtB-4npaA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 6 ILE A 255
ILE A 305
LEU A 301
PHE A 298
 None
 0.80A 5vkqA-4npaA:
undetectable
5vkqB-4npaA:
undetectable		 5vkqA-4npaA:
13.94
5vkqB-4npaA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 6 ILE A 255
ILE A 305
LEU A 301
PHE A 298
 None
 0.78A 5vkqA-4npaA:
undetectable
5vkqD-4npaA:
undetectable		 5vkqA-4npaA:
13.94
5vkqD-4npaA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 6 TYR A 111
LEU A 106
GLU A  23
LEU A  19
 None
 1.38A 5xooA-4npaA:
undetectable		 5xooA-4npaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 5 LEU A 106
VAL A 110
GLU A  23
LEU A  19
 None
 0.60A 5xooB-4npaA:
undetectable		 5xooB-4npaA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4npa PUTATIVE
UNCHARACTERIZED
PROTEIN
(Vibrio
cholerae) 		4 / 6 PRO A 195
ILE A 161
TYR A 166
GLU A 165
 None
 0.87A 6gqiA-4npaA:
undetectable		 6gqiA-4npaA:
22.38