SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4npb PROTEIN DISULFIDE
ISOMERASE II
(Yersinia
pestis) 		4 / 4 VAL A  83
THR A  84
VAL A  57
GLY A  70
 None
 1.20A 2p2fB-4npbA:
undetectable		 2p2fB-4npbA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4npb PROTEIN DISULFIDE
ISOMERASE II
(Yersinia
pestis) 		4 / 7 ASP A 116
PHE A 144
GLY A 148
THR A 118
 None
 1.14A 3vnsA-4npbA:
undetectable		 3vnsA-4npbA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4npb PROTEIN DISULFIDE
ISOMERASE II
(Yersinia
pestis) 		5 / 11 TYR A 141
VAL A 113
ILE A 111
MET A 223
LEU A 227
 None
 1.18A 4lhmA-4npbA:
undetectable		 4lhmA-4npbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4npb PROTEIN DISULFIDE
ISOMERASE II
(Yersinia
pestis) 		3 / 3 MET A 174
MET A 163
TYR A 141
 None
 1.37A 4p6xI-4npbA:
undetectable		 4p6xI-4npbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4npb PROTEIN DISULFIDE
ISOMERASE II
(Yersinia
pestis) 		3 / 3 ILE A  45
PRO A  46
ILE A  48
 None
 0.36A 5hw8F-4npbA:
undetectable		 5hw8F-4npbA:
19.91