SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 9 GLY A  23
ASP A  47
ILE A  48
ALA A  98
ILE A 120
 None
 0.81A 1cetA-4npcA:
11.0		 1cetA-4npcA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 THR A 117
ASN A 119
ASP A 115
TRP A 114
 None
 1.30A 1mxdA-4npcA:
2.2		 1mxdA-4npcA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		8 / 11 GLY A  23
ALA A  25
SER A  26
ASP A  47
ASP A  70
VAL A  71
ALA A  98
VAL A 100
 None
 0.70A 1uayA-4npcA:
31.0		 1uayA-4npcA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		8 / 10 GLY A  23
ALA A  25
SER A  26
ASP A  47
ASP A  70
VAL A  71
ALA A  98
VAL A 100
 None
 0.70A 1uayB-4npcA:
31.6		 1uayB-4npcA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 10 TYR A 163
ILE A 157
ALA A 152
ILE A 109
GLU A 158
 None
 1.30A 2dm6A-4npcA:
9.4
2dm6B-4npcA:
9.1		 2dm6A-4npcA:
24.21
2dm6B-4npcA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		3 / 3 ASP A  47
ASP A  51
ASP A  70
 None
 0.69A 2igtA-4npcA:
7.4		 2igtA-4npcA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		3 / 3 ASP A  47
ASP A  51
ASP A  70
 None
 0.69A 2igtB-4npcA:
8.0		 2igtB-4npcA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 9 ALA A 162
TYR A 163
ALA A 152
GLY A 153
ILE A 157
 None
 1.13A 2v7bA-4npcA:
4.6		 2v7bA-4npcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 9 ALA A 162
TYR A 163
ALA A 152
GLY A 153
ILE A 157
 None
 1.11A 2v7bB-4npcA:
4.7		 2v7bB-4npcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 10 ASP A  47
ILE A  48
ALA A  25
ASP A  70
VAL A  71
 None
 1.18A 3ay0A-4npcA:
2.3		 3ay0A-4npcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 10 GLY A  24
ASP A  47
ILE A  48
ASP A  70
VAL A  71
 None
 1.13A 3ay0B-4npcA:
6.9		 3ay0B-4npcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 11 VAL A  43
ALA A  64
GLY A  29
ILE A  93
GLY A  24
 None
 1.13A 3zosA-4npcA:
undetectable
3zosB-4npcA:
undetectable		 3zosA-4npcA:
21.34
3zosB-4npcA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 GLY A  29
GLY A  24
GLY A  23
LEU A 148
VAL A 196
 None
None
None
ACT  A 301 (-4.2A)
None
 0.89A 4htfA-4npcA:
7.2		 4htfA-4npcA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 GLY A  29
GLY A  24
GLY A  23
LEU A 148
VAL A 196
 None
None
None
ACT  A 301 (-4.2A)
None
 0.90A 4htfB-4npcA:
7.2		 4htfB-4npcA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4npc SORBITOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 ALA A  44
LEU A  46
ILE A 171
GLY A 245
LEU A 235
 None
 0.91A 5eshA-4npcA:
undetectable		 5eshA-4npcA:
18.50