SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		3 / 3 LEU A 427
ARG A 144
ILE A 424
 None
 0.67A 2xn5B-4nphA:
undetectable		 2xn5B-4nphA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 GLY A 153
ILE A 135
PHE A 354
PRO A 355
THR A 358
 None
 1.20A 3bjwF-4nphA:
undetectable		 3bjwF-4nphA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 LYS A 168
GLY A 165
ILE A 160
SER A 162
ARG A 259
 None
 1.30A 3gyqA-4nphA:
undetectable
3gyqB-4nphA:
undetectable		 3gyqA-4nphA:
24.31
3gyqB-4nphA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 ILE A 300
PHE A 231
ILE A 189
VAL A 187
VAL A 185
 None
 1.14A 3iw1A-4nphA:
undetectable		 3iw1A-4nphA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		3 / 3 ALA A 145
ARG A 144
LYS A 426
 None
 0.88A 3kp3B-4nphA:
undetectable		 3kp3B-4nphA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		3 / 3 ALA A 145
ARG A 144
LYS A 426
 None
 1.03A 3kp5B-4nphA:
undetectable		 3kp5B-4nphA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 ILE A 143
ASP A 147
THR A 141
ILE A 329
PRO A 342
 None
 1.10A 3kpbA-4nphA:
undetectable		 3kpbA-4nphA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 ILE A 143
ASP A 147
THR A 141
ILE A 329
PRO A 342
 None
 1.13A 3kpbC-4nphA:
undetectable		 3kpbC-4nphA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		3 / 3 SER A 332
ASP A 345
GLN A 377
 None
 0.94A 4oltA-4nphA:
undetectable
4oltB-4nphA:
undetectable		 4oltA-4nphA:
21.69
4oltB-4nphA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 10 LEU A 230
LEU A 254
ALA A 251
LEU A 325
LEU A 249
 None
 0.86A 4p65A-4nphA:
undetectable
4p65B-4nphA:
undetectable
4p65F-4nphA:
undetectable
4p65H-4nphA:
undetectable		 4p65A-4nphA:
5.99
4p65B-4nphA:
8.98
4p65F-4nphA:
8.98
4p65H-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 11 LEU A 230
LEU A 254
ALA A 251
LEU A 249
LEU A 325
 None
 0.86A 4p65C-4nphA:
undetectable
4p65D-4nphA:
undetectable
4p65J-4nphA:
undetectable
4p65L-4nphA:
undetectable		 4p65C-4nphA:
5.99
4p65D-4nphA:
8.98
4p65J-4nphA:
8.98
4p65L-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 11 LEU A 249
LEU A 325
LEU A 230
LEU A 254
ALA A 251
 None
 0.81A 4p65B-4nphA:
undetectable
4p65D-4nphA:
undetectable
4p65G-4nphA:
undetectable
4p65H-4nphA:
undetectable		 4p65B-4nphA:
8.98
4p65D-4nphA:
8.98
4p65G-4nphA:
5.99
4p65H-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 LEU A 325
LEU A 249
LEU A 230
LEU A 254
ALA A 251
 None
 0.83A 4p65B-4nphA:
undetectable
4p65D-4nphA:
undetectable
4p65I-4nphA:
undetectable
4p65J-4nphA:
undetectable		 4p65B-4nphA:
8.98
4p65D-4nphA:
8.98
4p65I-4nphA:
5.99
4p65J-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 LEU A 249
LEU A 325
LEU A 230
LEU A 254
ALA A 251
 None
 0.86A 4p65F-4nphA:
undetectable
4p65H-4nphA:
undetectable
4p65K-4nphA:
undetectable
4p65L-4nphA:
undetectable		 4p65F-4nphA:
8.98
4p65H-4nphA:
8.98
4p65K-4nphA:
5.99
4p65L-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		3 / 3 GLN A 377
SER A 332
ASP A 345
 None
 0.92A 4qwpA-4nphA:
undetectable
4qwpB-4nphA:
undetectable		 4qwpA-4nphA:
22.25
4qwpB-4nphA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		4 / 7 VAL A 346
ILE A 329
HIS A 362
LEU A 423
 None
 1.07A 4xo7B-4nphA:
undetectable		 4xo7B-4nphA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 11 TYR A 304
LEU A 249
VAL A 187
ILE A 189
ALA A 284
 None
 1.19A 5gpgA-4nphA:
undetectable		 5gpgA-4nphA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 ILE A 160
LEU A 325
GLY A 327
THR A 292
ALA A 318
 None
 1.13A 5x5qB-4nphA:
undetectable		 5x5qB-4nphA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN
(Salmonella
enterica) 		5 / 12 LEU A 254
TYR A 304
ALA A 233
LEU A 172
LEU A 249
 None
 1.28A 6ie8A-4nphA:
undetectable		 6ie8A-4nphA:
21.29