SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 ILE A 418
SER A 427
TRP A 438
LEU A 491
LEU A 458
 None
 1.02A 1s19A-4npkA:
undetectable		 1s19A-4npkA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		3 / 3 PRO A 463
ASP A 466
ASP A 413
 None
CA  A 803 (-3.1A)
CA  A 801 (-3.3A)
 0.77A 1sqfA-4npkA:
undetectable		 1sqfA-4npkA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 11 GLY A 416
TYR A 415
PHE A 459
VAL A 494
GLU A 455
 None
 1.36A 2fl5A-4npkA:
undetectable
2fl5B-4npkA:
2.7
2fl5F-4npkA:
2.6		 2fl5A-4npkA:
23.53
2fl5B-4npkA:
22.90
2fl5F-4npkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 7 ASP A 628
THR A 630
ILE A 539
ASN A 587
 None
 1.10A 2jc9A-4npkA:
undetectable		 2jc9A-4npkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 LEU A 458
LEU A 397
ILE A 418
SER A 435
TRP A 488
 None
 1.16A 3aqiB-4npkA:
undetectable		 3aqiB-4npkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 9 PHE A 489
LEU A 503
VAL A 479
LEU A 472
ILE A 474
 None
 1.04A 3tbgD-4npkA:
undetectable		 3tbgD-4npkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 12 PHE A 391
GLY A 416
ILE A 418
LEU A 499
PHE A 489
 None
 0.96A 4pd4C-4npkA:
undetectable		 4pd4C-4npkA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		5 / 10 LEU A 657
LEU A 506
VAL A 479
LEU A 476
VAL A 420
 None
 1.11A 4po0A-4npkA:
undetectable		 4po0A-4npkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4npk EXTENDED
SYNAPTOTAGMIN-2
(Homo
sapiens) 		4 / 5 PHE A 391
LEU A 397
GLY A 470
ILE A 418
 None
 0.93A 5ik1A-4npkA:
undetectable		 5ik1A-4npkA:
22.78