SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 8 ARG A 208
SER A 150
VAL A 179
SER A 155
 AKG  A 301 (-3.0A)
AKG  A 301 ( 4.8A)
None
None
 1.12A 1hwkA-4nplA:
undetectable		 1hwkA-4nplA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 8 ARG A 208
SER A 150
VAL A 179
SER A 155
 AKG  A 301 (-3.0A)
AKG  A 301 ( 4.8A)
None
None
 1.16A 1hwkC-4nplA:
undetectable		 1hwkC-4nplA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 8 ARG A 208
SER A 150
VAL A 179
SER A 155
 AKG  A 301 (-3.0A)
AKG  A 301 ( 4.8A)
None
None
 1.17A 1hwkD-4nplA:
undetectable		 1hwkD-4nplA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 GLY A  67
ASN A 119
ILE A 146
LEU A 187
VAL A 186
 None
 1.14A 1r30A-4nplA:
undetectable		 1r30A-4nplA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 GLY A  67
ASN A 119
ILE A 146
LEU A 187
VAL A 186
 None
 1.13A 1r30B-4nplA:
undetectable		 1r30B-4nplA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 VAL A  42
ILE A 211
LEU A 102
ALA A 209
ASP A  97
 None
 0.98A 2iyfB-4nplA:
undetectable		 2iyfB-4nplA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 ILE A 212
ARG A  61
ILE A  20
THR A 185
PHE A 159
 AKG  A 301 (-4.9A)
None
None
None
None
 1.44A 3ijdB-4nplA:
undetectable		 3ijdB-4nplA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 7 ASN A 124
ASP A 137
ILE A 132
HIS A 197
 AKG  A 301 (-3.1A)
MN  A 300 (-2.8A)
AKG  A 301 (-4.3A)
MN  A 300 ( 3.4A)
 1.03A 3t01A-4nplA:
undetectable		 3t01A-4nplA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 SER A  18
VAL A  16
ALA A 192
ALA A 191
GLY A  19
 None
 1.34A 5tzoA-4nplA:
undetectable		 5tzoA-4nplA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		5 / 12 SER A  18
VAL A  16
ALA A 192
ALA A 191
GLY A  19
 None
 1.33A 5tzoC-4nplA:
undetectable		 5tzoC-4nplA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 7 SER A 148
SER A 150
GLY A 182
ARG A 208
 AKG  A 301 ( 4.6A)
AKG  A 301 ( 4.8A)
None
AKG  A 301 (-3.0A)
 0.99A 6btxA-4nplA:
undetectable		 6btxA-4nplA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4npl RNA DEMETHYLASE
ALKBH5
(Danio
rerio) 		4 / 5 HIS A 135
ASP A 137
HIS A 197
ARG A 214
 MN  A 300 ( 3.3A)
MN  A 300 (-2.8A)
MN  A 300 ( 3.4A)
AKG  A 301 ( 4.6A)
 0.99A 6dchA-4nplA:
5.3		 6dchA-4nplA:
21.47