SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4npr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		3 / 3 ALA A 216
VAL A 116
TRP A 137
 None
 1.02A 1gmkA-4nprA:
undetectable
1gmkB-4nprA:
undetectable		 1gmkA-4nprA:
5.71
1gmkB-4nprA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		3 / 3 PHE A 196
LEU A 122
MET A 174
 None
 0.65A 1mx1D-4nprA:
undetectable		 1mx1D-4nprA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		5 / 12 LEU A 199
VAL A  96
LEU A 211
LEU A 122
VAL A 136
 None
 1.15A 1sn5B-4nprA:
undetectable
1sn5D-4nprA:
undetectable		 1sn5B-4nprA:
19.92
1sn5D-4nprA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		4 / 5 LEU A 141
PRO A 220
ALA A 114
ILE A 112
 None
 0.93A 2aofB-4nprA:
undetectable		 2aofB-4nprA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		5 / 12 ALA A 144
GLY A 143
GLY A 142
ALA A 140
THR A 184
 None
 1.10A 2c49A-4nprA:
undetectable		 2c49A-4nprA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		5 / 12 GLY A 204
ILE A 134
LEU A 122
LEU A 168
LEU A 166
 None
 1.35A 3cs8A-4nprA:
undetectable		 3cs8A-4nprA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		3 / 3 LYS A 104
TRP A 103
SER A 187
 None
 1.01A 5nwwA-4nprA:
undetectable		 5nwwA-4nprA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12
(Aspergillus
niveus) 		3 / 3 GLN A 215
TYR A  37
ASN A  83
 None
 1.04A 6dwdC-4nprA:
undetectable		 6dwdC-4nprA:
20.19