SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 VAL A  74
ALA A  70
ILE A  24
LEU A  20
ILE A  34
 None
 1.14A 1d1gB-4nq3A:
undetectable		 1d1gB-4nq3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 11 TRP A 245
ALA A   4
LEU A  91
ILE A  37
ALA A  36
 SO4  A 407 (-4.6A)
None
None
None
None
 1.04A 1ha2A-4nq3A:
undetectable		 1ha2A-4nq3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		3 / 3 PHE A  93
LEU A 239
MET A 241
 None
 0.83A 1mx1D-4nq3A:
undetectable		 1mx1D-4nq3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.03A 1ra3A-4nq3A:
undetectable		 1ra3A-4nq3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 0.99A 1rd7B-4nq3A:
undetectable		 1rd7B-4nq3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 HIS A 151
ILE A 144
GLY A 110
VAL A 135
ALA A 134
 None
 1.15A 1tlsB-4nq3A:
undetectable		 1tlsB-4nq3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aB-4nq3A:
undetectable		 2c8aB-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aD-4nq3A:
undetectable		 2c8aD-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 8 ARG A 188
HIS A 338
GLN A 339
THR A 177
 BR8  A 401 (-4.1A)
None
None
BR8  A 408 (-3.3A)
 1.35A 2vxaF-4nq3A:
2.5
2vxaG-4nq3A:
2.4
2vxaI-4nq3A:
2.5		 2vxaF-4nq3A:
12.76
2vxaG-4nq3A:
12.76
2vxaI-4nq3A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.14A 2w3bB-4nq3A:
undetectable		 2w3bB-4nq3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 GLY A 194
VAL A 131
ILE A 212
GLN A 339
 None
 0.90A 3fi0E-4nq3A:
undetectable		 3fi0E-4nq3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 GLY A 194
VAL A 131
ILE A 212
GLN A 339
 None
 0.87A 3fi0P-4nq3A:
undetectable		 3fi0P-4nq3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A   9
LEU A  59
THR A  26
 None
 1.17A 4cd2A-4nq3A:
undetectable		 4cd2A-4nq3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 HIS A 151
ILE A 144
GLY A 110
VAL A 135
ALA A 134
 None
 1.23A 4fqsA-4nq3A:
undetectable		 4fqsA-4nq3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 HIS A 151
ILE A 144
GLY A 110
VAL A 135
ALA A 134
 None
 1.23A 4fqsB-4nq3A:
undetectable		 4fqsB-4nq3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 8 ILE A 144
ALA A 198
GLU A 201
VAL A 238
 None
 0.80A 4jltA-4nq3A:
undetectable		 4jltA-4nq3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.11A 4m6kA-4nq3A:
undetectable		 4m6kA-4nq3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		3 / 3 ARG A 222
HIS A 253
SER A 220
 None
 1.00A 4mjwA-4nq3A:
undetectable
4mjwB-4nq3A:
undetectable		 4mjwA-4nq3A:
22.32
4mjwB-4nq3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.05A 4qi9A-4nq3A:
undetectable		 4qi9A-4nq3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 GLU A 201
SER A 220
ILE A 195
VAL A 153
 None
 0.99A 4tvtA-4nq3A:
undetectable		 4tvtA-4nq3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 GLY A 273
LEU A 107
LEU A 239
ALA A 348
HIS A 151
 None
 1.21A 4wcxC-4nq3A:
undetectable		 4wcxC-4nq3A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.07A 4x5fA-4nq3A:
undetectable		 4x5fA-4nq3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ILE A  24
ALA A  28
ILE A  37
LEU A  59
THR A  26
 None
 1.06A 4x5fB-4nq3A:
undetectable		 4x5fB-4nq3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 LEU A 239
LEU A 107
ILE A 109
GLU A  73
LEU A 283
 None
 0.92A 4y0sA-4nq3A:
undetectable		 4y0sA-4nq3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 5 SER A 308
GLU A 337
SER A 226
GLN A 154
 None
None
BR8  A 401 (-3.4A)
None
 1.48A 5fhrB-4nq3A:
undetectable		 5fhrB-4nq3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 SER A 220
HIS A 338
GLU A 287
GLY A 336
GLY A 334
 None
None
MG  A 409 (-3.3A)
MG  A 409 (-3.9A)
BR8  A 401 (-3.6A)
 1.09A 5l6eA-4nq3A:
undetectable		 5l6eA-4nq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 10 ALA A   4
VAL A   6
PHE A  38
ILE A  37
VAL A 237
 None
 1.13A 5nukA-4nq3A:
undetectable		 5nukA-4nq3A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ALA A 223
GLY A 336
GLU A 337
GLY A 335
LEU A 122
 None
MG  A 409 (-3.9A)
None
None
None
 1.20A 5ul4A-4nq3A:
undetectable		 5ul4A-4nq3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ASP A  49
GLY A  39
GLY A  80
PHE A  90
VAL A  77
 None
None
BR8  A 401 (-3.2A)
None
None
 1.31A 6clxA-4nq3A:
undetectable		 6clxA-4nq3A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 6 MET A 125
ALA A 196
LEU A 197
ALA A 132
 None
 1.17A 6fosB-4nq3A:
undetectable		 6fosB-4nq3A:
13.20