SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 ILE A 185
ALA A 179
THR A 229
PRO A 210
ASN A 209
 None
None
None
None
PAF  A 401 (-2.9A)
 1.05A 1dhfA-4nq8A:
undetectable		 1dhfA-4nq8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 PRO A 160
ALA A 298
PHE A 108
PHE A 297
 None
 1.21A 1lqtA-4nq8A:
undetectable		 1lqtA-4nq8A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 GLY A 146
TYR A 233
SER A 212
HIS A  39
 None
 1.04A 1maaD-4nq8A:
undetectable		 1maaD-4nq8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 7 GLY A 146
TYR A 233
SER A 212
HIS A  39
 None
 1.10A 2ackA-4nq8A:
undetectable		 2ackA-4nq8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 VAL A 271
ASP A 272
GLU A 144
 None
 0.59A 2qeuA-4nq8A:
undetectable		 2qeuA-4nq8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		3 / 3 VAL A 271
ASP A 272
GLU A 144
 None
 0.60A 2qeuC-4nq8A:
undetectable		 2qeuC-4nq8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 THR A 178
VAL A 232
GLY A 102
THR A 101
 SO4  A 402 (-3.1A)
None
None
None
 0.95A 3cflA-4nq8A:
undetectable		 3cflA-4nq8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 GLY A 146
GLY A 234
HIS A 231
VAL A 213
HIS A 176
 None
None
None
PAF  A 401 ( 4.9A)
None
 1.33A 4c5nB-4nq8A:
undetectable		 4c5nB-4nq8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 116
SER A 319
MET A 128
LEU A 316
VAL A 103
 None
 1.40A 4eilC-4nq8A:
undetectable		 4eilC-4nq8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 116
SER A 319
MET A 128
LEU A 316
VAL A 103
 None
 1.39A 4eilE-4nq8A:
undetectable		 4eilE-4nq8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 116
SER A 319
MET A 128
LEU A 316
VAL A 103
 None
 1.36A 4kyaA-4nq8A:
undetectable		 4kyaA-4nq8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 116
SER A 319
MET A 128
LEU A 316
VAL A 103
 None
 1.38A 4kyaE-4nq8A:
undetectable		 4kyaE-4nq8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 11 ALA A 116
SER A 319
MET A 128
LEU A 316
VAL A 103
 None
 1.39A 4kyaG-4nq8A:
undetectable		 4kyaG-4nq8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 ALA A  33
SER A  67
GLY A  71
GLU A 208
GLY A  92
 PAF  A 401 ( 4.0A)
None
None
None
None
 1.18A 4r29B-4nq8A:
undetectable		 4r29B-4nq8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.11A 5axaA-4nq8A:
undetectable		 5axaA-4nq8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.10A 5axaC-4nq8A:
undetectable		 5axaC-4nq8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.13A 5hm8A-4nq8A:
undetectable		 5hm8A-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5hm8B-4nq8A:
undetectable		 5hm8B-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5hm8C-4nq8A:
undetectable		 5hm8C-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.13A 5hm8D-4nq8A:
undetectable		 5hm8D-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5hm8E-4nq8A:
undetectable		 5hm8E-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.13A 5hm8F-4nq8A:
undetectable		 5hm8F-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.12A 5hm8G-4nq8A:
undetectable		 5hm8G-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5hm8H-4nq8A:
undetectable		 5hm8H-4nq8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.14A 5v96A-4nq8A:
undetectable		 5v96A-4nq8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.17A 5v96B-4nq8A:
undetectable		 5v96B-4nq8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.13A 5v96C-4nq8A:
undetectable		 5v96C-4nq8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 GLU A 172
THR A 171
THR A 101
LEU A 237
 None
PAF  A 401 (-4.5A)
None
None
 1.11A 5v96D-4nq8A:
undetectable		 5v96D-4nq8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 ILE A  51
SER A  50
ALA A 254
LEU A 248
 None
 0.98A 6dwnA-4nq8A:
undetectable		 6dwnA-4nq8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4nq8 PUTATIVE PERIPLASMIC
SUBSTRATE-BINDING
TRANSPORT PROTEIN
(Bordetella
bronchiseptica) 		4 / 6 ILE A  51
GLY A  57
TYR A  59
GLU A  52
 None
 0.91A 6gqiA-4nq8A:
undetectable		 6gqiA-4nq8A:
20.40