SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B 141
CYH B 131
GLY B 129
GLY B 128
 ZN  B 503 (-2.3A)
ZN  B 503 (-2.3A)
None
None
 0.91A 1ekjA-4nqaB:
undetectable
1ekjB-4nqaB:
undetectable		 1ekjA-4nqaB:
19.69
1ekjB-4nqaB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B 144
CYH B 125
GLY B 127
GLY B 128
 ZN  B 503 (-2.3A)
ZN  B 503 (-2.2A)
None
None
 0.78A 1ekjA-4nqaB:
undetectable
1ekjB-4nqaB:
undetectable		 1ekjA-4nqaB:
19.69
1ekjB-4nqaB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B 141
CYH B 131
GLY B 129
GLY B 128
 ZN  B 503 (-2.3A)
ZN  B 503 (-2.3A)
None
None
 0.86A 1ekjG-4nqaB:
undetectable
1ekjH-4nqaB:
undetectable		 1ekjG-4nqaB:
19.69
1ekjH-4nqaB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B 144
CYH B 125
GLY B 127
GLY B 128
 ZN  B 503 (-2.3A)
ZN  B 503 (-2.2A)
None
None
 0.75A 1ekjG-4nqaB:
undetectable
1ekjH-4nqaB:
undetectable		 1ekjG-4nqaB:
19.69
1ekjH-4nqaB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 CYH B 107
ARG B 138
CYH B 104
 ZN  B 502 (-2.3A)
None
ZN  B 502 (-2.3A)
 1.48A 1p9gA-4nqaB:
undetectable		 1p9gA-4nqaB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 CYH B 144
ARG B 147
CYH B 125
 ZN  B 503 (-2.3A)
None
ZN  B 503 (-2.2A)
 1.48A 1p9gA-4nqaB:
undetectable		 1p9gA-4nqaB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4nqa LIVER X NUCLEAR
RECEPTOR BETA
(Homo
sapiens) 		4 / 5 SER B 380
ARG B 383
PRO B 384
VAL B 386
 None
 1.42A 3sufC-4nqaB:
undetectable		 3sufC-4nqaB:
18.85