SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4nqw ANTI-SIGMA-K FACTOR
RSKA
ECF RNA POLYMERASE
SIGMA FACTOR SIGK
(Mycobacterium
tuberculosis) 		4 / 5 THR A  54
THR A  55
THR B  62
HIS A  85
 None
 1.10A 1d4fB-4nqwA:
undetectable		 1d4fB-4nqwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK
(Mycobacterium
tuberculosis) 		5 / 11 SER A  51
ALA A  84
LEU A  40
GLY A  39
ALA A 176
 None
 1.15A 4l6v1-4nqwA:
undetectable
4l6v6-4nqwA:
undetectable		 4l6v1-4nqwA:
14.74
4l6v6-4nqwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK
(Mycobacterium
tuberculosis) 		5 / 9 SER A  51
ALA A  84
LEU A  40
GLY A  39
ALA A 176
 None
 1.14A 4l6va-4nqwA:
undetectable
4l6vf-4nqwA:
undetectable		 4l6va-4nqwA:
14.74
4l6vf-4nqwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 158
GLU A 157
LEU A 177
ALA A 148
ARG A 174
 None
 1.12A 5nd7B-4nqwA:
undetectable		 5nd7B-4nqwA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4nqw ECF RNA POLYMERASE
SIGMA FACTOR SIGK
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  21
SER A  67
ARG A  64
 None
 0.90A 5u63A-4nqwA:
undetectable		 5u63A-4nqwA:
21.23