SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 10 VAL A  64
PHE A  45
VAL A   8
VAL A   6
LEU A  67
 None
 1.26A 1fe2A-4nreA:
1.1		 1fe2A-4nreA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 ASP A  60
PHE A   4
VAL A  64
 None
 0.75A 1kijB-4nreA:
undetectable		 1kijB-4nreA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.72A 1rjoA-4nreA:
undetectable		 1rjoA-4nreA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.68A 1rkyA-4nreA:
undetectable		 1rkyA-4nreA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.72A 1w2zB-4nreA:
undetectable		 1w2zB-4nreA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.70A 1w2zD-4nreA:
undetectable		 1w2zD-4nreA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 11 LEU A  94
LEU A 102
VAL A  27
GLY A  31
ARG A  30
 None
 1.03A 1y4lB-4nreA:
undetectable		 1y4lB-4nreA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 9 THR A 409
LEU A 410
HIS A 394
LEU A 402
LEU A 142
 None
 1.19A 2azqA-4nreA:
undetectable		 2azqA-4nreA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.73A 2oqeC-4nreA:
undetectable		 2oqeC-4nreA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.73A 2oqeF-4nreA:
undetectable		 2oqeF-4nreA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 12 LEU A 317
PHE A 242
LEU A 326
ILE A 331
SER A 320
 None
 1.37A 2pnjB-4nreA:
undetectable		 2pnjB-4nreA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 5 SER A 557
HIS A 373
LEU A 607
SER A 611
 GOL  A 718 (-2.0A)
C8E  A 702 ( 3.5A)
C8E  A 702 ( 4.3A)
None
 1.36A 2qhfA-4nreA:
undetectable		 2qhfA-4nreA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.70A 2w0qA-4nreA:
undetectable		 2w0qA-4nreA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.70A 2w0qB-4nreA:
undetectable		 2w0qB-4nreA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 6 LEU A  67
PHE A 104
LEU A  94
PHE A   4
 None
 0.97A 3abkP-4nreA:
undetectable
3abkW-4nreA:
undetectable		 3abkP-4nreA:
18.02
3abkW-4nreA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.73A 3hiiB-4nreA:
undetectable		 3hiiB-4nreA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 5 THR A 639
SER A 636
SER A 489
ARG A 486
 None
 1.28A 3hlwB-4nreA:
undetectable		 3hlwB-4nreA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 8 ASP A 291
LEU A 257
LEU A 289
CYH A 254
 None
None
None
SO4  A 707 (-3.5A)
 0.97A 3lm8A-4nreA:
undetectable
3lm8C-4nreA:
undetectable		 3lm8A-4nreA:
15.19
3lm8C-4nreA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 7 GLN A 560
HIS A 373
GLU A 671
PRO A 614
 None
C8E  A 702 ( 3.5A)
GOL  A 718 ( 4.8A)
None
 1.20A 3ql6A-4nreA:
undetectable		 3ql6A-4nreA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 12 ASP A 428
VAL A 427
ILE A 435
GLY A 437
ILE A 298
 None
C8E  A 702 ( 4.2A)
None
None
None
 1.06A 3spkB-4nreA:
undetectable		 3spkB-4nreA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 7 PHE A 184
TYR A 176
HIS A 411
HIS A 378
 None
None
None
C8E  A 702 ( 2.6A)
 1.08A 4g5jA-4nreA:
undetectable		 4g5jA-4nreA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 GLU A  32
THR A 115
HIS A  70
 None
 0.84A 4q15A-4nreA:
undetectable		 4q15A-4nreA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 GLU A  32
THR A 115
HIS A  70
 None
 0.83A 4q15B-4nreA:
undetectable		 4q15B-4nreA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 THR A 580
ASN A 340
SER A 341
 None
 0.54A 4tvtA-4nreA:
undetectable		 4tvtA-4nreA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 9 PHE A 365
LEU A 570
VAL A 426
VAL A 603
LEU A 420
 None
None
C8E  A 702 ( 4.0A)
C8E  A 702 ( 4.1A)
C8E  A 702 (-3.6A)
 1.29A 4wnvA-4nreA:
1.3		 4wnvA-4nreA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 11 PHE A 547
ASP A 459
ALA A 554
VAL A 556
GLY A 477
 None
None
GOL  A 718 (-2.9A)
None
None
 1.24A 4xnxA-4nreA:
2.1		 4xnxA-4nreA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 7 SER A 675
TYR A 408
GLU A 613
GLU A 671
 GOL  A 718 ( 4.6A)
SO4  A 710 (-4.8A)
GOL  A 718 (-3.3A)
GOL  A 718 ( 4.8A)
 1.48A 4xzkA-4nreA:
undetectable		 4xzkA-4nreA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 GLU A  32
THR A 115
HIS A  70
 None
 0.81A 4ydqB-4nreA:
undetectable		 4ydqB-4nreA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 6 TYR A 623
HIS A 405
ARG A 407
ASN A 672
 None
 1.37A 4zbqA-4nreA:
undetectable		 4zbqA-4nreA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 6 ARG A 407
ASP A 625
HIS A 627
ILE A 403
 None
SO4  A 711 ( 4.8A)
None
None
 1.35A 5a06A-4nreA:
undetectable		 5a06A-4nreA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 ASP A 625
LEU A 389
ARG A 145
 SO4  A 711 ( 4.8A)
None
None
 0.92A 5e8qA-4nreA:
undetectable		 5e8qA-4nreA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 8 ALA A 558
SER A 611
HIS A 373
HIS A 368
 GOL  A 718 (-3.2A)
None
C8E  A 702 ( 3.5A)
None
 1.14A 5km8A-4nreA:
undetectable
5km8B-4nreA:
undetectable		 5km8A-4nreA:
13.27
5km8B-4nreA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 6 PHE A 367
PHE A 365
ILE A 433
THR A 431
 None
None
None
C8E  A 702 ( 4.6A)
 1.15A 5vceA-4nreA:
undetectable		 5vceA-4nreA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 5 LEU A  67
PHE A 104
LEU A  94
PHE A   4
 None
 0.91A 5x19C-4nreA:
undetectable
5x19J-4nreA:
undetectable		 5x19C-4nreA:
18.02
5x19J-4nreA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		3 / 3 SER A 550
HIS A 405
TYR A 623
 None
 0.97A 5y2tA-4nreA:
undetectable		 5y2tA-4nreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 5 TYR A 154
LYS A 152
GLY A 424
ILE A 421
 None
 1.49A 6debB-4nreA:
undetectable		 6debB-4nreA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		5 / 12 ILE A 435
GLY A 434
ILE A 433
THR A 431
ILE A 421
 None
None
None
C8E  A 702 ( 4.6A)
None
 0.96A 6emuC-4nreA:
undetectable		 6emuC-4nreA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 8 GLY A 432
GLN A 308
THR A 300
SER A 366
 None
 1.16A 6eqpA-4nreA:
undetectable		 6eqpA-4nreA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens) 		4 / 6 LEU A 289
ASP A 291
ARG A 252
GLN A 335
 None
None
SO4  A 707 (-3.5A)
None
 1.31A 6g31J-4nreA:
undetectable		 6g31J-4nreA:
7.63