SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nrq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 11 HIS A 204
ASP A 206
HIS A 266
ARG A 277
SER A 219
 MN  A 302 ( 3.6A)
MN  A 302 ( 2.7A)
MN  A 302 ( 3.3A)
PD2  A 301 (-2.7A)
PD2  A 301 ( 4.5A)
 1.46A 1uofA-4nrqA:
8.1		 1uofA-4nrqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 12 ILE A 281
ARG A 130
ILE A  89
THR A 254
PHE A 228
 None
 1.28A 3ijdB-4nrqA:
undetectable		 3ijdB-4nrqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		4 / 7 ASN A 193
ASP A 206
ILE A 201
HIS A 266
 PD2  A 301 (-3.3A)
MN  A 302 ( 2.7A)
PD2  A 301 (-4.8A)
MN  A 302 ( 3.3A)
 1.06A 3t01A-4nrqA:
undetectable		 3t01A-4nrqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		3 / 3 ARG A 213
GLU A 212
PHE A 186
 None
 0.94A 4kszA-4nrqA:
undetectable		 4kszA-4nrqA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 12 VAL A 191
ALA A 190
PHE A 134
VAL A 161
GLY A 136
 None
 0.82A 4mm6A-4nrqA:
undetectable		 4mm6A-4nrqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 12 SER A  87
VAL A  85
ALA A 261
ALA A 260
GLY A  88
 None
 1.35A 5tzoA-4nrqA:
undetectable		 5tzoA-4nrqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		5 / 12 SER A  87
VAL A  85
ALA A 261
ALA A 260
GLY A  88
 None
 1.34A 5tzoC-4nrqA:
undetectable		 5tzoC-4nrqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens) 		4 / 7 SER A 217
SER A 219
GLY A 251
ARG A 277
 PD2  A 301 ( 4.9A)
PD2  A 301 ( 4.5A)
None
PD2  A 301 (-2.7A)
 1.08A 6btxA-4nrqA:
undetectable		 6btxA-4nrqA:
19.52