SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4nru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 GLY A 259
LEU A 280
VAL A 275
PHE A 202
 None
 1.02A 1gsfC-4nruA:
undetectable		 1gsfC-4nruA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 GLY A 190
SER A 119
ILE A 160
ASP A 278
 None
 0.84A 1jg4A-4nruA:
undetectable		 1jg4A-4nruA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 PRO A 214
HIS A 313
SER A 310
GLU A 345
 None
 1.03A 1jtvA-4nruA:
undetectable		 1jtvA-4nruA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 SER A  71
ILE A 292
GLU A 296
GLY A 297
 None
 0.92A 1meiA-4nruA:
undetectable		 1meiA-4nruA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		3 / 3 ASP A 412
LEU A 415
HIS A 478
 None
 0.55A 1qknA-4nruA:
undetectable		 1qknA-4nruA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 9 ARG A 405
ILE A 411
ALA A 448
LEU A 443
VAL A 485
 None
 1.34A 3o01A-4nruA:
undetectable
3o01B-4nruA:
undetectable		 3o01A-4nruA:
19.62
3o01B-4nruA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		9 / 9 ASP A 247
SER A 300
THR A 305
THR A 306
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
 None
None
None
None
None
2NG  A1101 ( 4.8A)
None
None
MG  A1102 (-3.4A)
 0.22A 3sfuA-4nruA:
57.2		 3sfuA-4nruA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		8 / 9 ASP A 247
THR A 306
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
LEU A 391
 None
None
None
2NG  A1101 ( 4.8A)
None
None
MG  A1102 (-3.4A)
2NG  A1101 ( 4.1A)
 0.27A 3sfuB-4nruA:
56.7		 3sfuB-4nruA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		10 / 11 LYS A 166
LEU A 184
ASP A 247
LEU A 298
SER A 300
THR A 305
THR A 306
ASN A 309
GLY A 342
ASP A 343
 None
 0.31A 3sfuC-4nruA:
57.7		 3sfuC-4nruA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		7 / 7 PRO A  38
GLY A  40
ALA A  41
TRP A  42
ALA A 409
ASP A 412
ARG A 413
 None
 0.65A 3ur0B-4nruA:
56.4		 3ur0B-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		7 / 9 GLY A  40
ALA A  41
TRP A  42
ALA A 409
ASP A 412
ARG A 413
LEU A 416
 None
 0.52A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 9 PRO A  38
GLY A  40
ALA A  41
TRP A  42
ALA A 409
 None
 0.73A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 11 GLN A  66
GLU A 168
LYS A 180
ARG A 245
ARG A 392
 None
None
None
None
2NG  A1101 (-3.7A)
 0.86A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		6 / 11 TRP A  42
GLN A  66
GLU A 168
VAL A 170
LYS A 180
ARG A 245
 None
 0.32A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		6 / 11 TRP A  42
GLN A  66
VAL A 170
LYS A 174
LYS A 180
ARG A 245
 None
 0.85A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 ARG A  53
GLU A  52
GLY A  48
THR A  25
 None
 0.86A 5sxqA-4nruA:
0.8		 5sxqA-4nruA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 ARG A  53
GLU A  52
GLY A  48
THR A  25
 None
 0.86A 5sxqB-4nruA:
0.7		 5sxqB-4nruA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 8 ARG A  53
GLU A  52
GLY A  48
THR A  25
 None
 0.87A 5syjA-4nruA:
undetectable		 5syjA-4nruA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 LEU A  94
THR A  97
TYR A 341
THR A 306
GLU A 337
 None
None
2NG  A1101 ( 4.8A)
None
None
 1.27A 5v1tA-4nruA:
undetectable		 5v1tA-4nruA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 PHE A 338
ALA A 253
LEU A  83
ILE A  82
LEU A 316
 None
 1.23A 6aybA-4nruA:
undetectable		 6aybA-4nruA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		3 / 3 ARG A 231
HIS A 232
ARG A 216
 None
 1.07A 6dwdD-4nruA:
undetectable		 6dwdD-4nruA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0B-4nruA:
undetectable		 6ew0B-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0D-4nruA:
undetectable		 6ew0D-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0F-4nruA:
undetectable		 6ew0F-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.09A 6ew0G-4nruA:
undetectable		 6ew0G-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0H-4nruA:
undetectable		 6ew0H-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		5 / 12 VAL A 324
ASP A 354
ALA A 320
LEU A 367
LEU A 379
 None
 1.08A 6ew0I-4nruA:
undetectable		 6ew0I-4nruA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 4 ASP A  16
ILE A 160
PRO A 159
LEU A 284
 None
 1.09A 6mkeB-4nruA:
undetectable		 6mkeB-4nruA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4nru RNA DEPENDENT RNA
POLYMERASE
(Norwalk
virus) 		4 / 4 ASP A  16
ILE A 160
PRO A 159
LEU A 284
 None
 1.12A 6mkeA-4nruA:
undetectable		 6mkeA-4nruA:
9.37