SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ns1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 11 ALA A  41
ILE A  81
GLY A  96
TYR A 104
ALA A  70
 None
 1.10A 1b02A-4ns1A:
undetectable		 1b02A-4ns1A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		6 / 10 GLY A 131
GLU A 208
GLY A 225
MET A 226
THR A 249
ASN A 250
 DA  A 301 (-3.4A)
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-4.1A)
DA  A 301 (-3.0A)
 0.52A 1pwyE-4ns1A:
38.1		 1pwyE-4ns1A:
45.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		6 / 10 GLY A 131
GLU A 208
GLY A 225
MET A 226
THR A 249
ASN A 250
 DA  A 301 (-3.4A)
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-4.1A)
DA  A 301 (-3.0A)
 0.39A 1v3qE-4ns1A:
38.5		 1v3qE-4ns1A:
45.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		4 / 6 PHE A 255
GLY A 132
GLY A 131
ASN A 261
 GOL  A 304 (-4.8A)
None
DA  A 301 (-3.4A)
DA  A 301 ( 4.8A)
 0.98A 2qr2A-4ns1A:
2.3
2qr2B-4ns1A:
undetectable		 2qr2A-4ns1A:
20.85
2qr2B-4ns1A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		6 / 6 GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
 DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
 0.42A 3e9rA-4ns1A:
39.8		 3e9rA-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		4 / 6 GLY A 225
TYR A 207
GLU A 208
GLY A 204
 DA  A 301 (-3.5A)
None
DA  A 301 (-2.7A)
None
 1.03A 3e9rA-4ns1A:
39.8		 3e9rA-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		6 / 6 GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
 DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
 0.43A 3e9rC-4ns1A:
39.7		 3e9rC-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		4 / 6 GLY A 225
TYR A 207
GLU A 208
GLY A 204
 DA  A 301 (-3.5A)
None
DA  A 301 (-2.7A)
None
 1.03A 3e9rC-4ns1A:
39.7		 3e9rC-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		9 / 12 SER A  46
ALA A 129
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 SO4  A 302 (-2.7A)
SO4  A 302 ( 3.4A)
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.82A 3f8wA-4ns1A:
38.8		 3f8wA-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		9 / 12 TYR A 101
ALA A 129
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 None
SO4  A 302 ( 3.4A)
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.37A 3f8wA-4ns1A:
38.8		 3f8wA-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		9 / 12 HIS A  99
TYR A 101
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 SO4  A 302 (-4.0A)
None
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.36A 3f8wB-4ns1A:
38.7		 3f8wB-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		8 / 12 SER A  46
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 SO4  A 302 (-2.7A)
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.77A 3f8wB-4ns1A:
38.7		 3f8wB-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		10 / 12 HIS A  99
TYR A 101
ALA A 129
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 SO4  A 302 (-4.0A)
None
SO4  A 302 ( 3.4A)
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.36A 3f8wC-4ns1A:
38.7		 3f8wC-4ns1A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		9 / 12 SER A  46
ALA A 129
GLY A 131
TYR A 207
GLU A 208
GLY A 225
MET A 226
ASN A 250
VAL A 266
 SO4  A 302 (-2.7A)
SO4  A 302 ( 3.4A)
DA  A 301 (-3.4A)
None
DA  A 301 (-2.7A)
DA  A 301 (-3.5A)
DA  A 301 (-4.0A)
DA  A 301 (-3.0A)
DA  A 301 ( 4.7A)
 0.82A 3f8wC-4ns1A:
38.7		 3f8wC-4ns1A:
45.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 10 VAL A 198
VAL A 200
LEU A 202
GLY A 221
VAL A 219
 CSO  A 146 ( 4.8A)
None
None
None
None
 1.16A 3ls4H-4ns1A:
undetectable		 3ls4H-4ns1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A  47
GLY A  45
ALA A 269
ALA A 272
LEU A  51
 None
SO4  A 302 (-3.2A)
None
None
None
 1.07A 3mteA-4ns1A:
undetectable		 3mteA-4ns1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 9 LEU A  86
THR A  89
VAL A  91
LEU A  48
ILE A  42
 None
 1.20A 3tbgD-4ns1A:
undetectable		 3tbgD-4ns1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		4 / 5 LEU A 284
ILE A 144
ALA A 187
MET A 245
 None
 1.06A 4dc3B-4ns1A:
undetectable		 4dc3B-4ns1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		4 / 7 MET A 106
HIS A 148
GLY A 201
ASN A 150
 None
 1.19A 5a5zC-4ns1A:
undetectable		 5a5zC-4ns1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 12 ALA A  93
LEU A  44
ILE A  43
GLY A 278
ILE A  55
 None
 1.07A 5m24A-4ns1A:
undetectable		 5m24A-4ns1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		5 / 12 GLU A 102
PRO A 205
GLU A 208
THR A 249
GLY A 131
 None
None
DA  A 301 (-2.7A)
DA  A 301 (-4.1A)
DA  A 301 (-3.4A)
 1.21A 5xioA-4ns1A:
undetectable		 5xioA-4ns1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Porphyromonas
gingivalis) 		3 / 3 HIS A 148
ASN A 150
LEU A 152
 None
 0.70A 6f7lB-4ns1A:
undetectable		 6f7lB-4ns1A:
19.87