SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ns4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 10 GLY A  49
PHE A  50
SER A 116
MET A 117
HIS A 266
 None
 0.69A 1a8uA-4ns4A:
28.4		 1a8uA-4ns4A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 10 GLY A  49
PHE A  50
SER A 116
MET A 117
HIS A 266
 None
 0.68A 1a8uB-4ns4A:
28.4		 1a8uB-4ns4A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 7 ARG A 197
MET A 174
ILE A 270
ASN A  56
 None
 1.23A 2zseA-4ns4A:
undetectable		 2zseA-4ns4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 8 GLY A 143
VAL A 216
ASP A 214
ILE A 211
 None
 0.79A 3fi0B-4ns4A:
undetectable		 3fi0B-4ns4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 8 GLY A 143
VAL A 216
ASP A 214
ILE A 211
 None
 0.71A 3fi0G-4ns4A:
undetectable		 3fi0G-4ns4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 7 GLY A 143
VAL A 216
ASP A 214
ILE A 211
 None
 0.73A 3fi0P-4ns4A:
undetectable		 3fi0P-4ns4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 11 SER A  80
LEU A 101
LEU A  25
ILE A  70
SER A  22
 None
 1.21A 3h6tA-4ns4A:
undetectable
3h6tC-4ns4A:
undetectable		 3h6tA-4ns4A:
20.36
3h6tC-4ns4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 11 ALA A  61
ARG A  62
ILE A  71
LEU A  18
ALA A  34
 None
 1.26A 3kw2B-4ns4A:
undetectable		 3kw2B-4ns4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 LYS A  15
ARG A  59
LYS A 307
 None
 1.44A 3okxA-4ns4A:
undetectable		 3okxA-4ns4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 THR A 260
ASP A 140
GLU A 271
 None
 0.82A 3qowA-4ns4A:
undetectable		 3qowA-4ns4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 12 LEU A 313
LEU A  64
LEU A  44
ALA A 303
TYR A 306
 None
 1.08A 3vw7A-4ns4A:
undetectable		 3vw7A-4ns4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 LEU A  97
ARG A  96
MET A  84
 None
 0.77A 4m11C-4ns4A:
undetectable		 4m11C-4ns4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 LEU A 100
ARG A  96
MET A  84
 None
 0.99A 4m11C-4ns4A:
undetectable		 4m11C-4ns4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 ILE A 121
ASP A 214
ARG A  96
 None
 0.67A 4pstA-4ns4A:
undetectable		 4pstA-4ns4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 6 GLY A  51
GLU A 204
ARG A 197
ASN A 200
 None
 1.16A 4zbqA-4ns4A:
undetectable		 4zbqA-4ns4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		3 / 3 THR A 260
ASP A 140
GLU A 271
 None
 0.80A 5fa8A-4ns4A:
undetectable		 5fa8A-4ns4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		4 / 8 LEU A 101
PRO A  43
ILE A  70
LEU A 100
 None
 0.92A 5g48A-4ns4A:
undetectable		 5g48A-4ns4A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 12 VAL A 216
ILE A 253
ALA A 126
ALA A 127
ILE A 223
 None
 0.94A 5kb6B-4ns4A:
undetectable		 5kb6B-4ns4A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Psychrobacter
cryohalolentis) 		5 / 12 ILE A 121
PRO A  72
LEU A  97
GLY A  49
GLY A 118
 None
 1.15A 5l6eA-4ns4A:
undetectable		 5l6eA-4ns4A:
20.87